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How Can Nutrigenomic Testing Tell You What Nutrition You Need and Don't Need

Coffee with Dr. Stewart

Podcast Show Date: April 21, 2016

Kara Stewart-Mullens: Neurobiologix proudly presents season two of Coffee with Dr. Stewart. This show will provide our listeners with up to date medical information from a leading neurotologist and neuro-immune specialist. With Dr. Stewartís broad medical knowledge, we will discuss how he helps his patients with issues such as ADD, migraines, hormones, sleep, fatigue, methylation, autism, genetic mutations, and nutritional protocols. I am your host Kara Stewart-Mullens and I invite you to sit back, grab your favorite beverage or cup of coffee and letís have coffee with Dr. Stewart. Welcome everybody to another episode of Coffee with Dr. Stewart. I am your host Kara Stewart-Mullens and today we have a very special topic, Iím going to get right into it.

Weíre going to be talking about nutrigenomic testing with Dr. Stewart. Nutrigenomic testing is something that is fairly new I would say.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Itís on the cutting edge of science and nutrition and so Dr. Stewart is going to enlighten us on how it can help a patient and how it can help practitioners in their practice. Hi Dr. Stewart.

Dr. Stewart: Hi Kara. How are you?

Kara Stewart-Mullens: How are you?

Dr. Stewart: Oh. Iím going.

Kara Stewart-Mullens: You know Iím excited about today, right?

Dr. Stewart: (laughing) Sure.

Kara Stewart-Mullens: Because this is a project that I know that you were chosen forÖ

Dr. Stewart: Right.

Kara Stewart-Mullens: From a company which I cannot release the name yet, but you were chosen as the medical expert to get this testing down to a science, so to speak.

Dr. Stewart: Sure.

Kara Stewart-Mullens: So that it can make it easy for the patient to find the proper nutritional support, but also the practitioner whoís going to be offering the testing in their office.

Dr. Stewart: Sure.

Kara Stewart-Mullens: See the patient so they can make the right choices for them.

Dr. Stewart: Right. Weíre trying to basically streamline the process and whatís great about nutrigenomics is that it tells you what you need to take, but more importantly, it actually tells you what you donít need to take.

Kara Stewart-Mullens: Exactly and weíre going to get into that. So I just want to have you give the scienceÖthe definition Öand Wikipedia and all that is nutrigenomics is the science of the study of nutrients and genetic expression.

Dr. Stewart: Right.

Kara Stewart-Mullens: A lot of places say this is the future of medicine, but I want your definition of nutrigenomics.

Dr. Stewart: Well basically, what we used to do in medicine is we used to look at patient groups that were similar. So weíd treat them with a drug or weíd treat them with a supplement and weíd say how everybody worked out. Weíd say oh this percentage of people did well and this percentage didnít.

Kara Stewart-Mullens: Okay.

Dr. Stewart: What we now are able to do is weíre able to look at exactly how you an individual person, are builtÖ

Kara Stewart-Mullens: By genes?

Dr. Stewart: By genes and we are actually then able to tell you exactly how things are going to react in you.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So weíve gone from this kind of ridiculously simple concept of weíll just test a whole lot of people and see if we donít make any mistakes.

Kara Stewart-Mullens: What happens (laughing)Öhow they correlate? Right.

Dr. Stewart: Now what we are able to do is weíre able to tell what you individually need and how different you are from your sibling, from your other family members, and from other people. Itís just basically a way for us to recognize your strengths and your weaknesses.

Kara Stewart-Mullens: Youíve been doing pharmacogenetics for a few years now. Itís more popular now, which drugs work best based upon your genetic panel, but I mean it sounds like it would work for nutrition because itís got to go a certain way, down a pathway, correct?

Dr. Stewart: Correct. So thereís two parts to pharmacogenetics. One part is pharmacokinetics, how is the drug broken down in the body, what does the body do to the drug, and can you break it down properly, so you donít get toxic in it.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Then the more important part, which is really much more complex is pharmacodynamics, which means how does the drug react for you?

Kara Stewart-Mullens: Ah.

Dr. Stewart: Does it work for you or not work for you? Thereís a lot of complexity in all this area. Now actually, nutrigenomics, as a topic, really includes three major areas. One is the genomics itselfÖ

Kara Stewart-Mullens: Okay.

Dr. Stewart: Which is genome. Another one is the proteome, which is all the proteins that it makes, and how it reacts. Then we have to look at the metabolome, which is what is going on inside the cell, do we have toxins, do we have clearance, and all that type of stuff. So it gets really complicated.

Kara Stewart-Mullens: I was going to say this is not really easy.

Dr. Stewart: No.

Kara Stewart-Mullens: I mean youíve had your head deep in this research for quite some time now.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Thatís why you were chosen to be the expert.

Dr. Stewart: Sure. So with all that being said, instead of going to your doctor in the future and getting a blood test and saying this is what your blood test shows, youíre normal or youíre not normalÖ

Kara Stewart-Mullens: At that momentÖ

Dr. Stewart: Letís go from that. What weíre going to have to do is completely and to a certain degree, forget about all that and then go to the cell and say okay, well how does the cell react?

Kara Stewart-Mullens: And thatís involved with the genes?

Dr. Stewart: Thatís genes and how you express yourself.

Kara Stewart-Mullens: Okay. So weíve kind of got the understanding and I just want to tell people, this is not easy. A lot of people out there are getting their genetic testing on a 23 and ME. You know how many genetic SNPs come back that you have to look at?

Dr. Stewart: Well, so when you do a 23 and Me genetic test, youíre getting 1,000 pages of encrypted data.

Kara Stewart-Mullens: Which is ridiculous.

Dr. Stewart: Right. And so there are lots of genes in there, doom and gloom genes which are the ones I donít really like to look at.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Which is like oh you got an 80 percent chance of breast cancer.

Kara Stewart-Mullens: But that doesnít mean youíre going to get it.

Dr. Stewart: No and so I donít really like to look at those. Iím interested in helping people and not to say that those arenít helpful to know, but what Iím really interested in, in doom and gloom genes is how we turn them off.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Now as far as the genes we look at, we have to take that 23 and Me data and put it into an interpretation engine. It spits out about 400 genes of enzymes that we look at and so we have to kind of parse through 400 genes to get down to about 40 to 60 that are significant.

Kara Stewart-Mullens: A lot of doctors are trying to look at all of them and people are Googling them and coming up with so much misinformation out there on the internet.

Dr. Stewart: Well the answer is yes. If youíre not a chemist, see this is all about chemistry and if you donít know the chemistry, you donít know what the enzyme works on, how or what it produces, then you really canít understand it. All youíre left with is a bunch of information that doesnít make a lot of sense and how they all interact with each other and what important roles do they have.

Kara Stewart-Mullens: So when you look up SNP rs and you go to the internet, it tells you what it means, but you donít know if that is actually correlated with the rest of your SNPsÖ

Dr. Stewart: I hate to say it, but 90 percent of the time, those SNPs are not clinically important.

Kara Stewart-Mullens: Okay. Thatís what Iím getting to. Thatís the meat and potatoes of this. I mean thatís what you have to know and I am glad that youíre going to be able to educate practitioners out there.

Dr. Stewart: So what we did on our current project which Iím sure youíll mention is coming along here in the next few months, is we basically were able to take those 400 genes and find about 26 of them that were clinically important.

Kara Stewart-Mullens: Okay.

Dr. Stewart: And weíre able to put it into an easy package and then actually put information behind it that makes sense to doctors and theyíll be able to tell what you need and what you donít need.

Kara Stewart-Mullens: Thatís awesome.

Dr. Stewart: So thatísÖ

Kara Stewart-Mullens: And itís a cheek swab. Thereís no blood and thereís no spit involved. Itís just a cheek swab.

Dr. Stewart: Yep. Just a cheek swab.

Kara Stewart-Mullens: Okay. And then that doctor sends that test off and the report comes back to the patient and the doctor?

Dr. Stewart: Right. And in the futureÖ

Kara Stewart-Mullens: And then you tell them.

Dr. Stewart: I am going to tell you in the future, we may find some more, so that test will probably grow as we go. For now, the 26 really answers the major areas and the areas that we really are interested in are basically methylationÖ

Kara Stewart-Mullens: Okay. Of course.

Dr. Stewart:Mitochondrial function. You got to have energy.

Kara Stewart-Mullens: Very important.

Dr. Stewart: Bowel health.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Basically, what is really going on in your bowel from an enzyme standpoint, can you tolerate certain things, do you break down certain thingsÖ

Kara Stewart-Mullens: Ah.

Dr. Stewart: Weíre also interested in detoxification.

Kara Stewart-Mullens: Of course.

Dr. Stewart: Do you get rid of chemicals or do you not.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Okay. Lastly, the health of the immune system itself from a standpoint of what you were born with.

Kara Stewart-Mullens: And neurotransmitter, where does that fall into?

Dr. Stewart: The neurotransmitter breakdown kind of falls into the methylation pathways.

Kara Stewart-Mullens: Okay. Yeah because those are both significant.

Dr. Stewart: Thatís basically, how do you breakdown and process neurotransmitters.

Kara Stewart-Mullens: So instead of sitting there going oh this SNP, this SNP, this SNP, you can look at a category and you can see how it correlates to another category?

Dr. Stewart: Well the answer is yes because they all correlate together; they all work together. God makes a beautiful machine that works together. So you canít just go look at spark plugs in a car and you examine the spark plugs and not examine any other part of the car and say oh the car is fine.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Because what if it doesnít have any good gas in it?

Kara Stewart-Mullens: Well that leads me to everybodyís getting their methylation panel, their MTHFR and youíre like that is not enough.

Dr. Stewart: Not even close.

Kara Stewart-Mullens: So you have to look at the FOLRs, you have to look at the mitochondrial markers.

Dr. Stewart: Right.

Kara Stewart-Mullens: So what made you pick those 26 SNPs? From research or looking at your patientís case studies?

Dr. Stewart: Iíve read about 1500 genetic reports.

Kara Stewart-Mullens: Oh gosh. Thatís fun.

Dr. Stewart: So after reading all of those reports and correlating it to patients, those are just the ones that stood out as the ones that were the most important for us to understand how we could get you better.

Kara Stewart-Mullens: Have you ever seen the movie A Beautiful Mind?

Dr. Stewart: Yeah, I have.

Kara Stewart-Mullens: You know how he sees things and things pop out?

Dr. Stewart: Yeah. Thatís not (laughing)Ö

Kara Stewart-Mullens: (laughing) Thatís what I feel like you do. You see things and it lights up and you go thatís it after looking at 1,000 reports.

Dr. Stewart: No. Thatís notÖ

Kara Stewart-Mullens: Your photographic memory. Sorry to get off topic there, butÖ

Dr. Stewart: Thatís okay.

Kara Stewart-Mullens: You have to correlate all this by clinical study, right? By looking at your patients.

Dr. Stewart: Yes. Well the answer is if you get away from patients, you can write, you can do all the theoretical work you want. You can sit in the lab and do your genetics and find this gene and talk about the enzyme, but if you donít go see how it relates to people and patients and the troubles they get into and how you get them out of it, you have no understanding of what really goes on.

Kara Stewart-Mullens: Yeah. Thatís what I think separates you from a lot of the people.

Dr. Stewart: I didnít do any of the research.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Believe me, I am a master assimilator.

Kara Stewart-Mullens: Yep.

Dr. Stewart: I didnít do the research. That was all of those great scientists that sit up in those labs and study all these genes and SNPs and they come up with their little things and they report to the database. My job is to take it, look at it, understand it, compare it across a whole bunch of people, and find out whatís important and whatís not.

Kara Stewart-Mullens: And then share it with other practitioners so they can do the same?

Dr. Stewart: Sure. Well, make it easier because most of them donít think about chemistry the way I do.

Kara Stewart-Mullens: I talked to someone the other day, that said; ďI canít get into to see Dr. Stewart for six months and I want to get my genetic testing read.Ē We have on our Neurobiologix website a list of about 25 practitioners that we feel have been trained by you somewhat, but I think this is going to take it to a whole another level. We could have hundreds of practitioners out there doing this.

Dr. Stewart: Well sure because thatís where you want it, the problem with most of my patients is that they want to bring their whole family to see me and itís just not enough time.

Kara Stewart-Mullens: Yeah. Not enough time.

Dr. Stewart: We want to make it easy and I donít see easy patients. I like to see sick people because they really need the help even though I donít mind seeing healthy people.

Kara Stewart-Mullens: The average individual will benefit from this though.

Dr. Stewart: Oh but everybody benefits from this.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: If you donít know how youíre built, you donít know anything.

Kara Stewart-Mullens: Yeah. So youíre just wasting a bunch of money buying a bunch of stuff for takingÖ

Dr. Stewart: Yeah youíre buying a bunch of junk that you really donít necessarily need.

Kara Stewart-Mullens: Okay. Well when we are deciding what products we need, is this test actually going to tell us? I mean is what the basis of this test is for?

Dr. Stewart: Well, to a certain degree, yes. The answer is it tells us how certain things are manipulated and how theyíre created and how good you create them and how good they work. Now what Iíll tell you is that you canít just completely ignore laboratory testing in some of these, but comparing laboratory and genetics together, you get the mostÖ

Kara Stewart-Mullens: Ah.

Dr. Stewart: Complete picture.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So I canít tell you how much thyroid you have in your body by a genetic test.

Kara Stewart-Mullens: You got to get blood work.

Dr. Stewart: But I can tell you how strong your mitochondria is and how much thyroid you need to make that mitochondria work like a normal mitochondria.

Kara Stewart-Mullens: Oh okay. So itís a cross over?

Dr. Stewart: Or I canít tell what your vitamin D level is, but I can tell you whether you absorb it very well or not.

Kara Stewart-Mullens: Or what form?

Dr. Stewart: But youíll probably need more than the average person.

Kara Stewart-Mullens: All right, well with that said, weíre going to be right back with Coffee with Dr. Stewart and weíre going to talk about the categories that heís based his nutrigenomic testing on and weíre going to break them down for you. Weíll be right back.

Commercial Break: Have you recently heard the medical term methylation? Do you know what it could mean to you or your familyís health? Methylation is responsible for over 250 processes in the body and without proper methylation, this could mean the difference between a healthy life or a life of not feeling well. At Neurobiologix, our core mission is to help people understand what methylation means to them and create products to support the methylation process. If you or someone you know has issues with memory, mood, fatigue, headaches, stomach issues, recovery from exercise, then take a few moments to visit our website View our videos by leading physicians on methylation and what nutritional formulas may be right for you. Overcoming a methylation deficiency may not happen quickly, but it can be done. Neurobiologix pharmaceutical grade nutrition created by experts.

End Commercial Break

Kara Stewart-Mullens: All right and we are back with Coffee with Dr. Stewart. We are talking about nutrigenomic testing. Hi Dr. Stewart again.

Dr. Stewart: (laughing) Youíre fired up today.

Kara Stewart-Mullens: I am. Iím on that new product Mito Cell PQQ and it has raised the roof for me. I had to start slower actually. I needed to start at one capsule and then move up to two per your recommendation.

Dr. Stewart: Yeah. You got to start with one and thenÖ

Kara Stewart-Mullens: Yeah. Iíve got the mitochondrial markers. Well which leads into our next part of the show.

Dr. Stewart: Sure.

Kara Stewart-Mullens: The second half of the Nutrigenomics Show because weíre going to talk about the categories. So there are some tests out there that have 20 SNPs, 10 SNPs, 8 SNPs, methylation SNPs only, but they donít tell you how to correlate that. So Dr. Stewart with this company thatís releasing this in February of 2016, has it broken into categories so it makes it easier for the doctor to understand and then the patient to understand.

Dr. Stewart: Sure.

Kara Stewart-Mullens: So letís talk about the first category of the 26 SNPs that you have chosen, the methylation categories, and the biomarkers.

Dr. Stewart: Okay. Well methylation is basically just the ability to deliver nutritional elements related to the B vitamin. So itís methyl tetrahydrofolate, methyl B12, how you break it down, how you create it, how you deliver it, those things that are important with methylation.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Weíve talked about that extensively.

Kara Stewart-Mullens: You talked about the MTHFR of course is in there and then you haveÖ

Dr. Stewart: Sure.

Kara Stewart-Mullens: The FLORs.

Dr. Stewart: Sure.

Kara Stewart-Mullens: And I think once people seeÖ

Dr. Stewart: Just remember that MTHFR is only one of the multitude ofÖ

Kara Stewart-Mullens: One piece.

Dr. Stewart: Of the enzymes, so all the enzymes are important because they all take part in the process.

Kara Stewart-Mullens: Okay. So that seems to be the biggest panel of the SNPs.

Dr. Stewart: Well itís because thereís so many different layers to it.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Now remember thatís the gasoline for your car.

Kara Stewart-Mullens: If you donít have it none of the other parts will work.

Dr. Stewart: If you donít have methylation, if you donít have methyl tetrahydrofolate or methyl B12, nothingís going to work right.

Kara Stewart-Mullens: Okay. That part of the test, that panel, it will tell us if a patient needs more methyl B12, more methyl folate, different productsÖ

Dr. Stewart: It is able for me to quantify to a reasonable degree the effectiveness of your ability. So I can tell a patient you make 30 percent of whatís expected. You make 40 percent; you make 10 percent of whatís expected.

Kara Stewart-Mullens: Then you can tell them what to take?

Dr. Stewart: And then I can tell them how much to take.

Kara Stewart-Mullens: How much to take, thatís the key, right?

Dr. Stewart: Mm-hmm.

Kara Stewart-Mullens: Okay. Letís get down to the next panel, the neurotransmitter panel. This is important because this is brain function, right?

Dr. Stewart: Well itís notÖitís brain function, but what methylation relates to is how do we make neurotransmitters.

Kara Stewart-Mullens: Okay.

Dr. Stewart: What neurotransmitter genetics relate to is how well you break them down and turn them over. So whatís important to understand about the brain, is itís not signaling the next nerve, itís how fast can you signal the next nerve, get rid of the signal, and give another signal. How fast do you turn over the signal?

Kara Stewart-Mullens: Because if you donít turn it over, youíre going to be unfocused. Youíre going to beÖ

Dr. Stewart: Youíre sluggish.

Kara Stewart-Mullens: Sluggish.

Dr. Stewart: Youíre just sluggish.

Kara Stewart-Mullens: Is that where ADD/ADHD comes in as well?

Dr. Stewart: Well because when weíre sluggish and thinking God makes us very hyperaware of our surroundings.

Kara Stewart-Mullens: Yes.

Dr. Stewart: We get hypersensitive to everythingÖ

Kara Stewart-Mullens: You notice everything.

Dr. Stewart: It means at the end of the day, things start getting on my nerves when Iím tired, okay? Every mom and dad knows that, when you can tolerate a lot at the beginning of the day and at the end of the day, you have finally just had enough.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: So the COMTs, the MAOAs and Bs, theÖ

Kara Stewart-Mullens: These are all SNPs youíre talking about?

Dr. Stewart: Yes. These are all SNPs. These are how fast and how good do I break down dopamine, okay, and the monoamines and then thereís the GAD, I believe, thatís in there.

Kara Stewart-Mullens: Okay.

Dr. Stewart: And GAD tells me how well I convert glutamic acid to GABA.

Kara Stewart-Mullens: Okay.

Dr. Stewart: And GABA is your everythingís good with life neurotransmitter.

Kara Stewart-Mullens: Yep.

Dr. Stewart: Everythingís relaxed.

Kara Stewart-Mullens: I like GABA.

Dr. Stewart: GABA is good stuff and it also helps you initiate sleep and it actually gives you a more, I call it the half glass full concept.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Most people who make a lot of GABA see the glass as half glass full and people who donít make enough see it as half glass empty.

Kara Stewart-Mullens: Ah. Iím a half glass full kind of gal.

Dr. Stewart: I am too.

Kara Stewart-Mullens: Oh thatís good. Positivity, I like that.

Dr. Stewart: Iím not a gal though.

Kara Stewart-Mullens: (laughing) No youíre not with that big beard right now either.

Dr. Stewart: No.

Kara Stewart-Mullens: Yíall canít see thatÖ

Dr. Stewart: Thatís not a beardÖ

Kara Stewart-Mullens: Heís got a big beard or goatee, right.

Dr. Stewart: No, itís a beard, youíre right.

Kara Stewart-Mullens: Okay. Letís get on to the next group the neurotransmitters, just one question on that. If they come back with some homozygous status, which is two copies, on some of those neurotransmitter SNPs are a lot of those people in trouble with ADHD?

Dr. Stewart: Sure.

Kara Stewart-Mullens: Okay. Or sleep problems?

Dr. Stewart: So ADHD combines a lot of these different things.

Kara Stewart-Mullens: See thatís the correlation that people donít understand.

Dr. Stewart: No, thereís not one gene for ADHD.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Itís a methylation deficiency plus a mitochondrial weakness plus some problems breaking down the neurotransmitters so itís a complete syndrome from a genomic standpoint. There are multiple places where the problems are occurring.

Kara Stewart-Mullens: Thatís where I canít wait to get to the training because youíre going to be able to tell doctors.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Okay, this is not just this, itís this, this, this, and this.

Dr. Stewart: No. So thereís not one thing you can do for ADHD. You can do several things.

Kara Stewart-Mullens: Yeah. Thatís true. Okay getting to the next one, the bowel markers. Everybodyís wondering about gluten, histamine, bowel issues, probiotics, and how much do I need? So these SNPs that you have chosen in the bowel panel, tell us about it.

Dr. Stewart: It is not necessarily about knowing whether you are gluten sensitive. The way people get to this thing is do I have bowel pain or not when I eat the wrong things?

Kara Stewart-Mullens: Yeah.

Dr. Stewart: So there are a lot of different answers for that. It may be gluten sensitivities so we have a couple of markers that give us a higher risk of people who have these markers of having gluten sensitivity.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So you need to know whether you need to avoid gluten or not and as a general rule, gluten is crap food. So I really donít like it in general.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Even though I love to eat it, it doesnít mean itís good for me.

Kara Stewart-Mullens: What would be the marker for gluten?

Dr. Stewart: Thatís the HLA DQ one and two.

Kara Stewart-Mullens: So if you came back with a double mutation, a homozygousÖ

Dr. Stewart: Youíre probably going to want to be gluten avoidant.

Kara Stewart-Mullens: But you probably should get a food allergy panel?

Dr. Stewart: Sure. Eventually. Now the other two we put in there, the FUT2, it turns out that basically we secrete a sugar called a fucosyl sugar into the bowel to attract good bacteria.

Kara Stewart-Mullens: Oh okay.

Dr. Stewart: And people can be partial secretors or non-secretors.

Kara Stewart-Mullens: With the double mutation?

Dr. Stewart: So I tell my patients in a silly fashion because in Texas we use deer feeders, I said if you donít have any corn in your deer feeder, how many deer show up?

Kara Stewart-Mullens: None.

Dr. Stewart: The answer is none and everybody kind of gets that because the long and the short of it is, if youíre a non-secretor, youíre going to get a lot of dysbiosis or bowel overgrowth because the bad bacteria set in.

Kara Stewart-Mullens: Okay.

Dr. Stewart: And then we also haveÖ

Kara Stewart-Mullens: So that would mean that you need probiotics, right?

Dr. Stewart: Thatís probiotics all the time for that.

Kara Stewart-Mullens: Okay.

Dr. Stewart: And then DAO, which is diamine oxidaseÖwe actually have an enzyme in our bowel to break down histamines that occur in foods.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So certain foods like the nightshades like tomatoes and eggplants, spinach for instance, processed meats like lunchmeats, coffee, alcohol, all of those foods have histamines in them.

Kara Stewart-Mullens: Yep.

Dr. Stewart: Okay? And if you donít have this enzyme, youíll eat and it hurts like crap.

Kara Stewart-Mullens: Well it hurts like crap but also your face gets red or you get that allergic reaction on your skin.

Dr. Stewart: You can. Right. You can get a runny nose, you can get all kinds of things and so we have enzymes that break down histamine. Okay?

Kara Stewart-Mullens: Okay.

Dr. Stewart: So these people literally get, if theyíre bad enough, they can get welps in their bowel.

Kara Stewart-Mullens: Wow. Interesting.

Dr. Stewart: You understand? Itís from the histamine in the food, not the histamine from the immune system.

Kara Stewart-Mullens: So I guess our product, GI Hist, isÖ

Dr. Stewart: Would break it down. Thatís correct.

Kara Stewart-Mullens: Those two little tiny capsulesÖ

Dr. Stewart: And you just carry it with you and if you are going toÖ

Kara Stewart-Mullens: Feel that reaction?

Dr. Stewart: Right. You just start taking it.

Kara Stewart-Mullens: Yeah. That is a very popular product lately. So thatís interesting because I like it when I drink red wine interestingly enough.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Because I have that reaction.

Dr. Stewart: Thatís right.

Kara Stewart-Mullens: But I like my wine every now and then.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Okay. Letís get to the next category, the detox biomarkers. This is really important.

Dr. Stewart: Yeah detox is really important. In fact, in the patients that see me over the 1500 that Iíve read this year, 80 percent of them I would say have detox problems.

Kara Stewart-Mullens: Does that mean glutathione problems orÖ

Dr. Stewart: That means typically whatís happened is everybody thought about producing glutathione and when you methylate, you do produce more glutathione if you use an acetylcysteine and all these other things, but what people donít understand is that many people make a faulty form of glutathione.

Kara Stewart-Mullens: Yeah. You said that on our Mitochondrial Show.

Dr. Stewart: So once we learned that they made a faulty form, it doesnít really matter how much you make, itís a faulty form.

Kara Stewart-Mullens: Okay.

Dr. Stewart: It just doesnít bind very well. So in those people, we have to use glutathione to clear their toxins out.

Kara Stewart-Mullens: Oral, injectable, or topical, right?

Dr. Stewart: And then we also can look at some other liver enzymes that basically break down the system.

Kara Stewart-Mullens: Well let me ask you this on the glutathione. So if youíre making faulty glutathione because you have a mutationÖ

Dr. Stewart: Correct.

Kara Stewart-Mullens: Which mutation would it be on? I mean which SNP?

Dr. Stewart: GSTP and GSTM.

Kara Stewart-Mullens: Okay. So someoneís either homozygous or heterozygous in one of those. So theyíre probably going to need some glutathione support.

Dr. Stewart: Correct. Then we have the SOD mutations, which are in the cell, so when we create inflammation and even in cells, we create whatís called oxygen-free radicals. So SODs are what we call super oxide dismutase and we found out many, many people have problems with SOD2, which is in the mitochondria.

Kara Stewart-Mullens: Okay.

Dr. Stewart: SOD3, which is in the cell itself, and that means they canít break down free radicals. So those people need lots of glutathione and lots of high-level antioxidants like fruits and vegetables.

Kara Stewart-Mullens: Okay.

Dr. Stewart: They need those things to fight that because theyíre just not very good at breaking it down.

Kara Stewart-Mullens: So you just said SOD2, correct? Thatís in the detox biomarker panel, but it correlates to mitochondrial.

Dr. Stewart: Correct.

Kara Stewart-Mullens: So thatís why, I think, a lot of people are so confused out there like practitioners and patients.

Dr. Stewart: Sure they are.

Kara Stewart-Mullens: Because you have to figure out what correlates.

Dr. Stewart: But thatís the difference. Genome is not all; itís the microbiome too.

Kara Stewart-Mullens: What is microbiome?

Dr. Stewart: Okay the metabolome or the microbiome means whatís in the cell, what chemicals naturally and unnaturally are in the cell?

Kara Stewart-Mullens: Okay.

Dr. Stewart: So unfortunately, we have chemicals in our environment; pesticides, herbicides, all those and if we canít get rid of those, they are unfortunately in the cell causing havoc.

Kara Stewart-Mullens: Oh gosh. How do you get them out of the cell? Glutathione?

Dr. Stewart: Glutathione is the primary way.

Kara Stewart-Mullens: Okay. All right. So now letís get to the one of the big boys. I mean theyíre all big boys to me, but the mitochondrial biomarkers, the SNPsÖ

Dr. Stewart: Yeah. This is the real exciting area. This is kind of what we spent the last twoÖ

Kara Stewart-Mullens: Yeah part one and part two because itís so important.

Dr. Stewart: Right.

Kara Stewart-Mullens: Mitochondria.

Dr. Stewart: Talk about it, because listen, having bad batteries is not fun.

Kara Stewart-Mullens: No.

Dr. Stewart: Okay? Now there are some exciting things going on in relationship to understanding batteries. Weíre able to now actually induce the body, in most cases, to grow more mitochondria in the cell to create more energy. Basically, we can look at these genetic SNPs and I can pretty much tell you how strong your batteries are.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Meaning did you get gypped or did you get a really good set of batteries.

Kara Stewart-Mullens: And youíre talking about mitochondria?

Dr. Stewart: Now the problem is you have to also deliver methylation to the battery to make it work.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So thatís the juice.

Kara Stewart-Mullens: The twofold.

Dr. Stewart: And you have to have thyroid and you have to have progesterone and you have to have all these things that work well, but the long and the short of it is if youíve got a battery thatís not working well, you probably canít get out of trouble too.

Kara Stewart-Mullens: So these are really important SNPs?

Dr. Stewart: So this may even be the future where we could actually look at stem cell transplants from another family member.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Or from something like that.

Kara Stewart-Mullens: Wow, thatís exciting.

Dr. Stewart: Yeah and take out stem cells from one family member who has better genetics and put those into another family member who maybe doesnít get so lucky genetically.

Kara Stewart-Mullens: Wow. Okay and your last category, immune biomarkers. Really quick, weíre running out of time.

Dr. Stewart: Yeah the immune biomarkers just tell us how you were built, is your immune system genetically strong or not.

Kara Stewart-Mullens: And vitamin D is a big key to that?

Dr. Stewart: Yeah vitamin D is huge.

Kara Stewart-Mullens: Okay. Well Dr. Stewart, this is only the first show about your new nutrigenomic panel thatís coming out.

Dr. Stewart: Right.

Kara Stewart-Mullens: Iím really excited. I wish I could say the name, but I canít because itís really cool, but anyways, we thank you so much. This wraps up for 2015 of Coffee with Dr. Stewart. You can visit us at or Coffee with Dr. Stewart or email us at and weíd be happy to answer any questions you have. Dr. Stewart, I thank you for your time this year.

Dr. Stewart: Youíre very welcome.

Kara Stewart-Mullens: All right everybody and have a blessed and beautiful day.

Dr. Stewart: Merry Christmas.

Kara Stewart-Mullens: This show is intended for general information and entertainment purposes only. Dr. Stewart serves as the chief science officer and lead formulator for Neurobiologix and advises you to consult with your own medical professional on any information given during this programming. This information is not intended to diagnose, treat, or cure any disease or medical condition.