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Mitochondria and The Connection to Physical and Mental Fatigue - Part 1

Coffee with Dr. Stewart: Season 2 – Episode 10
Podcast Show Date: November 16, 2015

Listen in as we discuss with Dr. Kendal Stewart the importance of the mitochondria, how methylation and the mitochondria are correlated, and steps you can take to help your mitochondria nutritionally. To boost you mitochondrial function, order our Mito Cell PQQ formula today!

Kara Stewart-Mullens: Neurobiologix proudly presents season two of Coffee with Dr. Stewart. This show will provide our listeners with up to date medical information from a leading neurotologist and neuroimmune specialist. With Dr. Stewart’s broad medical knowledge, we will discuss how he helps his patients with issues such as ADD, migraines, hormones, sleep, fatigue, methylation, autism, genetic mutations, and nutritional protocols. I am your host Kara Stewart-Mullens and I invite you to sit back, grab your favorite beverage or cup of coffee and let’s have Coffee with Dr. Stewart. Alright and good afternoon everybody, thank you for joining us on another episode of Coffee with Dr. Stewart. I am Kara Stewart-Mullens, your host, and we are now on episode 10. Right, Dr. Stewart?

Dr. Stewart: Yeah.

Kara Stewart-Mullens: Can you believe it? Hasn’t it just flown by?

Dr. Stewart: Sounds like you had your coffee today.

Kara Stewart-Mullens: I did. I had a lot of coffee today (laughing).

Dr. Stewart: (laughing) You’re jacked up.

Kara Stewart-Mullens: I am. You know, that’s kind of my normal personality. Today we’re going to talk about mitochondria. I always choose a topic based upon all the calls and emails we get.

Dr. Stewart: Sure.

Kara Stewart-Mullens: I asked Dr. Stewart; “What do you want to talk about?” He said; “Mitochondria.”

Dr. Stewart: Mitochondria.

Kara Stewart-Mullens: So we’re going to cover mitochondria and chronic fatigue today.

Dr. Stewart: Sure.

Kara Stewart-Mullens: I first want to start out, Dr. Stewart, I got an email last week that brought me to tears. We get a lot of emails from patients of yours or just from people that say; “Oh my gosh, your supplements or Dr. Stewart has changed my life.” This one was from an M.D. counterpart.

Dr. Stewart: Oh, okay.

Kara Stewart-Mullens: She’s a medical doctor. She’s an OB/GYN in Scottsdale, Arizona. Her name is Courtney Hunt. I’m not going to read the whole thing, but I’m going to read part of her email. So, "It is not often, Dr. Stewart, as healthcare providers, that we hear how deeply we have touched the lives of people we may never see or meet. I want to let you know that I have been greatly impacted by your practice of medicine. I have been searching for answers to hunches about pregnancy and autism. I have delivered thousands of babies and there’s always been a voice in my head getting stronger telling me that MTHFR plays a role.”

Dr. Stewart: That’s awesome.

Kara Stewart-Mullens: Yeah. So "Until last year when I saw you speak at A4M,” which is the World Congress of Anti-Aging, it changed her life.

Dr. Stewart: Oh that’s awesome.

Kara Stewart-Mullens: Yeah. So "Since that day in December, I have studied everything I can get my hands on about MTHFR, neurotransmitters, and immune problems. My husband suffers from celiac disease and there were days that I did not think he was going to survive.”

Dr. Stewart: Really?

Kara Stewart-Mullens: She has another family member that struggled with anxiety and depression his whole life. They both started on the supplements that you suggested and she says; “Now I have my boys back.”

Dr. Stewart: Oh that’s awesome. So good.

Kara Stewart-Mullens: Yeah. She says her husband is back to health that he had twelve years ago. He is up early and ready to go and even goes to the gym with her.

Dr. Stewart: That’s great.

Kara Stewart-Mullens: And her other family member is doing wonderful and not lethargic or disorganized. Doesn’t that make you just so proud and happy?

Dr. Stewart: Yes. I’m glowing.

Kara Stewart-Mullens: Wow. Well I can’t wait to talk about this topic. Mitochondria and chronic fatigue is stuff that you have been doing since I’ve known what you did in medicine. Ten to twelve years ago when we talked about chronic fatigue, we talked about herpes, and Epstein-Barr, but mitochondria, it’s something that I don’t think a lot of people understand what it is or what they do. So first let’s start out, because mitochondria and fatigue go hand in hand, correct?

Dr. Stewart: Sure.

Kara Stewart-Mullens: Tell us first what are mitochondria and what do they do.

Dr. Stewart: Well that’s right. Let me tell you why we’re talking about this. Beginning a couple of years ago, we started gaining access because of changes in genetic testing. Now we’ve always suspected that many people had mitochondrial disease, but the way we had to study it was by taking muscle biopsies and doing all kinds of invasive things in people who really just were massively fatigued and floppy babies, etc.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: We had to basically just touch on the genetics, but what happened beginning with genetic testing that was easily accessible, is we were able to start seeing the process by which the energy was made was manipulated in many people by single nucleotide polymorphisms…

Kara Stewart-Mullens: Well first let’s get a definition of mitochondria.

Dr. Stewart: I will.

Kara Stewart-Mullens: They’re the powerhouses of the cell, correct?

Dr. Stewart: Yes. What happens is mitochondria are your batteries.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So all cells need batteries and everybody understands this because if you think of an elderly lady, let’s think of somebody in their 80s and their mitochondria are starting to get weak.

Kara Stewart-Mullens: Yes.

Dr. Stewart: What’s the first thing that goes south?

Kara Stewart-Mullens: Their brain.

Dr. Stewart: Their brain and then their immune system starts to go, they get a little sicker.

Kara Stewart-Mullens: They get sick a lot.

Dr. Stewart: Okay and then eventually their muscles get weak, they can’t take care of themselves.

Kara Stewart-Mullens: Can’t walk…

Dr. Stewart: And are in the old folks’ home and then usually not with us too much longer.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: So everybody kind of understands what happens when mitochondria get weak, okay? In order to understand what we need to function properly, the brain needs the most energy of anything.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Okay? The immune system needs…

Kara Stewart-Mullens: And there’s a mitochondria in every cell in the brain?

Dr. Stewart: Mitochondria in every cell period.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Because you can’t function without energy.

Kara Stewart-Mullens: Okay.

Dr. Stewart: When we started looking at the immune system and the nervous system and we’re asking, “Okay, what is unique about these cells compared to other cells?” It really comes down to energy. We have to have more energy. You and I both know, if we don’t sleep very well, how good does our brain work the next day?

Kara Stewart-Mullens: Not good.

Dr. Stewart: Okay. So energy is really important. Now mitochondria are your powerhouses, they make ATP which is the energy of the cell and it makes it by a couple of ways. One way is splitting glucose which makes a small amount, but the majority of it is made inside these mitochondria.

Kara Stewart-Mullens: Okay.

Dr. Stewart: In fact, 90 percent of the energy of the cells is made in the mitochondria. So what we got interested in is how common is mitochondrial energy and what’s really unique about being able to look at genetics is I have never seen a person with perfect mitochondria.

Kara Stewart-Mullens: Okay.

Dr. Stewart: We all have some mild degree of mitochondria weakness…

Kara Stewart-Mullens: I know I do.

Dr. Stewart: Okay? Now that degree can be completely determined by genetics. So if you have 90 percent functional mitochondria, you are a super athlete running marathons.

Kara Stewart-Mullens: You’re doing really good.

Dr. Stewart: You’re playing pro sports; you’re doing fantastic stuff. Eighty percent, you’re still feeling pretty good. Seventy percent, you’re starting to get into trouble sometimes. Sixty percent and fifty percent and you’re in really big trouble. You understand?

Kara Stewart-Mullens: That’s kind of like what methylation, when you get into those…

Dr. Stewart: Well methylation is part of it. So what we’ve found when we deal with people who have neurological immunological energy problems, etc., is we have two required categories.

Kara Stewart-Mullens: Okay.

Dr. Stewart: We have a methylation problem and we have a mitochondrial problem because methylation, methyl tetrahydrofolate feeds mitochondria. You understand?

Kara Stewart-Mullens: Ah. Yes.

Dr. Stewart: So those are inter-related, you can’t separate them and one thing that is 100 percent so far in what we’ve seen, well I’m going to say 99 percent, okay because that’s what doctors say.

Kara Stewart-Mullens: Okay.

Dr. Stewart: We never say 100 percent, but in order to get into trouble with your nervous system and your immune system, you have to have a predisposition of low energy and low methylation together.

Kara Stewart-Mullens: Okay. I know recently you’ve been talking about these SNPs on the mitochondrial markers.

Dr. Stewart: Yes. Well a SNP is called a single nucleotide polymorphism.

Kara Stewart-Mullens: It’s a genetic mutation.

Dr. Stewart: It’s a genetic mutation where we find basically researchers, not me, on the assimilator. I’m not the researcher, but all these researchers put out their identifications of their genetic, unique discoveries and we have to then go look at them from a clinical perspective.

Kara Stewart-Mullens: Which you’re great at.

Dr. Stewart: Correct. And that’s what I do.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So I steal everybody’s research and put it all together, okay?

Kara Stewart-Mullens: (laughing) No reason to invent the wheel, I always say.

Dr. Stewart: Well I’m not a real…

Kara Stewart-Mullens: You’re not a researcher.

Dr. Stewart: I could be, have been…

Kara Stewart-Mullens: You’re very good at correlating your research. You can grab all these abstracts and white papers and look at it and assimilate it and put it all together.

Dr. Stewart: That’s what I love to do.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Okay? So what gets me so excited is we would methylate most people and they would feel better, just like the lady you mentioned.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Okay and that’s great, but then there were some people and I’d say probably…

Kara Stewart-Mullens: And your patients are pretty severe, so you have to get…

Dr. Stewart: My patients are not…

Kara Stewart-Mullens: Yeah. They always say they’re skewed because they’re pretty severe cases.

Dr. Stewart: But a lot of them would feel better, but they weren’t well. We were like okay why in the world are they not well?

Kara Stewart-Mullens: Okay.

Dr. Stewart: Well energy.

Kara Stewart-Mullens: Ah. So you have to go to the mitochondria?

Dr. Stewart: And so what’s happened…

Kara Stewart-Mullens: At the same time or do you start first with the mitochondria?

Dr. Stewart: Well you have to start with methylation first. Methylation is the gasoline.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So if I got to find out how a car’s going to run, I need to put gas in it first.

Kara Stewart-Mullens: Yep.

Dr. Stewart: Okay so we always start with methylation, but what we’re rapidly going to now that we have genetics, is we know how much inflammations in the body, we know how well you detox, we know how strong your mitochondria are, so we set the process with proof of what we’ve been talking about because up until last year, we were doing what we call theoretical biochemistry which means we were saying; “Oh look at this marker, if we go back to the biochemical pathway, this must have been where it got interrupted.” We don’t have to do that anymore.

Kara Stewart-Mullens: Yeah. Because you have patients that are floppy babies and we’d put them on the mitochondrial restore and some other things that you do in your clinic and they would start to pull themselves up and so you knew it was working, but now you have that genetic proof that this is what’s going on.

Dr. Stewart: That’s correct. So…

Kara Stewart-Mullens: That’s awesome.

Dr. Stewart: Obviously, you need energy to heal.

Kara Stewart-Mullens: Yep.

Dr. Stewart: So I tell people there are three rules to healing and its stuff I’ve mentioned before. Number one, we got to have inflammation control.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Got to get rid of the source of the inflammatory environment. Number two is having energy. Number three is having the right nutrition to heal whatever you’re after.

Kara Stewart-Mullens: You know what’s interesting is people with mitochondrial disease is not that common, but people with mitochondrial issues is very common. That’s like people that don’t have energy, first of all, maybe just minor fatigue, people that don’t recover from exercise, people that cannot heal after surgery…

Dr. Stewart: Yeah, low muscle tone, mmm-hmm.

Kara Stewart-Mullens: And just can’t get enough energy…

Dr. Stewart: Correct.

Kara Stewart-Mullens: So when you hear all these things, I’m like oh my gosh, well that’s me, you know?

Dr. Stewart: Right.

Kara Stewart-Mullens: That’s something that I go through, but I go in and out of it.

Dr. Stewart: Well then through the chronic fatigue, what you were finding is people correlating things. So if you don’t have good mitochondria and your immune cells don’t work right, then you will get Epstein-Barr, you will get herpes viruses, you will get yeast, you will get Lyme’s disease, you will get all these things because your immune system is not working well because it doesn’t have the right energy. It does not mean that the Epstein-Barr caused the chronic fatigue.

Kara Stewart-Mullens: It’s just one of the symptoms?

Dr. Stewart: It’s one of the secondary effects. If you’ve been infected with mono and you have crappy immune cells, guess what? Mono loves to try to take advantage of you.

Kara Stewart-Mullens: And it will hold onto you for a long time.

Dr. Stewart: So we have to get away from this correlation cause and effect meaning like I like to tell people, I drove to work and two blue cars had wrecks. So you know what, we should outlaw blue cars because they obviously have more wrecks. Sounds dumb, but that’s kind of how all these scientific studies come across when you look at them the way…

Kara Stewart-Mullens: Oh yeah. The blind placebos and this and that and they go, “Oh fifteen people had this effect so obviously it causes this.”

Dr. Stewart: Right.

Kara Stewart-Mullens: But you don’t know what’s going on with the rest of them.

Dr. Stewart: No. So the idea is, if we can strengthen the mitochondria and we can even talk about some other concepts which are…

Kara Stewart-Mullens: Well that might be part two. I think this is going to be a long episode, a two-part episode because we have a lot of things to talk about.

Dr. Stewart: I know. Okay.

Kara Stewart-Mullens: Tell me a little bit because you’ve been speaking about the herpes virus, Epstein-Barr and everything that was associated with mitochondrial issues, chronic fatigue, you’ve been doing that for fifteen years. People are saying, “Oh my gosh, he’s the anti-viral doctor or he’s doing this and that,” but now they’re all wanting to find your protocol because it’s obviously been working for so long and they’re finally realizing it.

Dr. Stewart: Well, you know, I got caught up in the same thing, treating the symptoms because that’s all we knew how to treat. But now that we kind of understand it, if I can fix the cells, the body fixes itself.

Kara Stewart-Mullens: That’s wonderful.

Dr. Stewart: So that’s the way, to me, the future of medicine. Meaning we still need medicines for acute issues, but we’re not going to put you on Valtrex for the rest of your life just to suppress the herpes if we don’t recognize that you have chronic herpes because your immune system is in trouble.

Kara Stewart-Mullens: So let’s fix the immune system?

Dr. Stewart: Fix the immune system.

Kara Stewart-Mullens: Okay. Well let’s take a quick break. When we get back, we’re going to talk more about this. Alright we’ll be right back with Coffee with Dr. Stewart.

[Commercial Break]

Kara Stewart-Mullens:

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[End Commercial Break]

Kara Stewart-Mullens:

Alright and we are back with episode 10 on Coffee with Dr. Stewart. We are talking about mitochondrial function, weakness, genetics with mitochondria. We’re also talking about some chronic fatigue issues and fatigue in general. Dr. Stewart, during the break, we were talking about when you look at the websites for mitochondrial disease, you see all these symptoms that people have. So you’ve got poor growth: muscle coordination issues; neurological problems; seizures; autism; hearing problems; development delays; heart, liver, kidney disease; GI issues; diabetes; and increased risk of infection. Now they’re associated with mitochondrial disease, but does that mean that you have that disease or the weakness?

Dr. Stewart: Okay. So a difference in a disease versus a weakness, which is what I like to say, is a disease from a mitochondria perspective is genetically that you have inherited a terrible function of one specific step in the mitochondria.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Meaning you’ve inherited this terrible complete blockade at a specific step. Now…

Kara Stewart-Mullens: Okay. And is very noticeable physically…

Dr. Stewart: Oh sure.

Kara Stewart-Mullens: In these people that are super severe?

Dr. Stewart: Everybody knows.

Kara Stewart-Mullens: The floppy babies…

Dr. Stewart: Yeah.

Kara Stewart-Mullens: The people that can’t walk very well…

Dr. Stewart: Yeah.

Kara Stewart-Mullens: They’re clumsy, things like that.

Dr. Stewart: But a lot of time, you’ll find out that those people don’t necessarily find a weakness in a specific thing, so you think they have it, but they don’t. So the difference in a weakness though is that we can have multiple points in the steps. A mitochondria has five different steps that you go through. It’s called the respiratory chain and basically, you go through five steps and then out pops energy. So we can have a mild weakness at step one, three, and four.

Kara Stewart-Mullens: Okay.

Dr. Stewart: We can have a mild weakness at one, three, and five. We can have a mild weakness at one, four, and five, but they add up to a generalized weakness.

Kara Stewart-Mullens: How do you know which weaknesses? By the genetic SNPs?

Dr. Stewart: By the genetic SNPs.

Kara Stewart-Mullens: And name a couple of those.

Dr. Stewart: NDUFS7 is the most common. That’s the one…

Kara Stewart-Mullens: That’s the one that everybody seems to have that mutation.

Dr. Stewart: Well if you’re patients that I see, most of them have it.

Kara Stewart-Mullens: I have it.

Dr. Stewart: That’s NDUFS7…

Kara Stewart-Mullens: Of course I do.

Dr. Stewart: And that uses NADH and converts it to NAD and basically what you’re doing in a mitochondria is you’re taking hydrogen molecules and you’re pushing them across a membrane and you’re creating an electrical potential. So these steps essentially push hydrogen molecules across, create this electrical potential and then we use that electrical potential to make ATP.

Kara Stewart-Mullens: Okay so eventually, it does go through all the steps, just not as well as it should or is it…

Dr. Stewart: Right.

Kara Stewart-Mullens: It was supposed to be?

Dr. Stewart: Correct. So when you add up ten percent, let’s say, of three steps, all of a sudden, you got a 70 percent function in a mitochondria. Now the problem is right now. We don’t know what the strength and the severity of each one step is, but if we see three people with three SNPs versus somebody with two versus somebody with five, we all of a sudden see clinically that the five person sure does feel a whole lot better.

Kara Stewart-Mullens: And a lot of these issues are in play?

Dr. Stewart: They’re all in play.

Kara Stewart-Mullens: Really?

Dr. Stewart: So the whole idea is we got to define the difference because the difference is we now know that we can actually more than likely induce all cells to grow more mitochondria.

Kara Stewart-Mullens: I love that. We do have the mitochondrial restore, which is great. I take it. A lot of people take it for when fatigue and stuff…

Dr. Stewart: Sure.

Kara Stewart-Mullens: What they always associate it with.

Dr. Stewart: Sure.

Kara Stewart-Mullens: There’s lots of reasons. But PQQ…

Dr. Stewart: Sure.

Kara Stewart-Mullens: Is what we’re adding and so tell us about that…

Dr. Stewart: Okay so…

Kara Stewart-Mullens: Because we’ve had great people come back, “Oh my gosh, I feel so much better.”

Dr. Stewart: So there’s three major ways that we can help it. So the number one step in the respiratory chain is basically NADH ubiquinone transferase…

Kara Stewart-Mullens: CoQ10?

Dr. Stewart: No. So we can talk about that, but it helps to make CoQ10, but basically that stuff can respond to NADH…

Kara Stewart-Mullens: Which is nicotinamide riboside…

Dr. Stewart: Nope. That’s nicotinamide…

Kara Stewart-Mullens: Gosh I’m just all wrong today. I thought that’s what it was. What is NADH?

Dr. Stewart: NADH is nicotine adenine diphosphate.

Kara Stewart-Mullens: Oh wonderful.

Dr. Stewart: Okay. Nicotinamide adenine diphosphate and basically that is the co-factor that you use for that stuff. Now niagen, which is what you’re referring to, is nicotinamide riboside which gets converted to NADH.

Kara Stewart-Mullens: Okay. So sometimes that can help?

Dr. Stewart: Sure. They both can help, but the problem is, that those will strengthen that step, but if you have weaknesses further along on the mitochondria, it won’t really help those steps.

Kara Stewart-Mullens: Okay.

Dr. Stewart: It can fix the first step or help it…

Kara Stewart-Mullens: Which will help, in some cases…

Dr. Stewart: Sure.

Kara Stewart-Mullens: Most cases…

Dr. Stewart: You’ll feel better.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: A lot of people feel better and that’s fairly instantaneous…

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Meaning you notice it within a week or two.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: That you are feeling better. Now the second one is really interesting. So PQQ which is called pyrroloquinoline quinone is basically a super potent form of CoQ10.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Okay? Now CoQ10 is mostly used in step three of the mitochondria. Now what happened is pyrroloquinoline quinone, when they started studying mice, they found out if they added more to a mouse…

Kara Stewart-Mullens: More PQQ?

Dr. Stewart: Mmm-hmm. To their diet, they actually grew more mitochondria and that came out…

Kara Stewart-Mullens: That’s amazing.

Dr. Stewart: In 2010. Then they all of a sudden went over to certain groups like Parkinson’s, Alzheimer’s, and dementia, you can certainly look at PQQ in these types of disease.

Kara Stewart-Mullens: Yeah I have. It’s amazing.

Dr. Stewart: And when they found that if they added dietary PQQ, we would typically create more energy in the cells by telling the cells to multiply their mitochondria.

Kara Stewart-Mullens: Wow.

Dr. Stewart: Now that takes time so it’s not like you’re going to take Cogni-Q…

Kara Stewart-Mullens: I’m not going to be an athlete…

Dr. Stewart: Any of those PQQ contending things and you’re not going to fix it overnight.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Yeah. So I’ve been on it now for twelve weeks…

Kara Stewart-Mullens: Okay.

Dr. Stewart: And at about six weeks is when I really started to notice that my appetite was up, my body fat started going down, my fatigue was gone…

Kara Stewart-Mullens: Yeah.

Dr. Stewart: My energy was better I really have to say…

Kara Stewart-Mullens: I notice that I can wake up easier in the morning.

Dr. Stewart: Sure.

Kara Stewart-Mullens: I used to be super lethargic. My eyes rolling back in my head and I can actually…

Dr. Stewart: Sure.

Kara Stewart-Mullens: Get up now.

Dr. Stewart: So the whole idea is that we essentially now know that, by using more PQQ in the majority of people, we can actually probably and I say probably because we really haven’t been able to completely prove it yet, induce the cell to grow more mitochondria. So if I have a battery that’s making 60 percent energy, if I can’t grow more batteries, then I’ve only got 60 percent energy, but eight batteries making 60 percent of energy versus four batteries making 60 percent…

Kara Stewart-Mullens: It’s so much better.

Dr. Stewart: It is much more energy for the cell.

Kara Stewart-Mullens: So the new formula that’s coming out in January, the Mito Cell PQQ, that’s with the….

Dr. Stewart: NADH.

Kara Stewart-Mullens: Oh NADH and PQQ.

Dr. Stewart: And PQQ and ubiquinone…

Kara Stewart-Mullens: Wow.

Dr. Stewart: All together.

Kara Stewart-Mullens: That’s why we have people calling.

Dr. Stewart: Correct.

Kara Stewart-Mullens: (laughing) You’re already telling them.

Dr. Stewart: Because we have that put altogether because those three things have shown and then we’ve put acetyl-l-carnitine, quercetin and resveratrol…

Kara Stewart-Mullens: Now I know we did. I know that you tried this on a few patients and you had amazing results.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Okay. So you’re planning that this is going to be a big change.

Dr. Stewart: It’s going to be a big one because you have to go buy separate bottles of all those things to help right now…

Kara Stewart-Mullens: And they’re expensive.

Dr. Stewart: Yep, they’re very expensive.

Kara Stewart-Mullens: PQQ is very expensive.

Dr. Stewart: So what you do, is you have to put them all together so that you have the best effect.

Kara Stewart-Mullens: And the right ratios?

Dr. Stewart: The only thing you have to watch out for and it’s just something to be aware of, is that the brain in people who have had weakness of mitochondria has adapted to having a low energy state. So when you put like NADH in, what will happen is all of a sudden, the brain will have more energy and a lot of people, it floods neurotransmitters and they can get a little emotional for a couple weeks.

Kara Stewart-Mullens: Oh yeah.

Dr. Stewart: Okay? In fact, I got a little bit irritable for a couple of days…

Kara Stewart-Mullens: No, not you. Did you cry?

Dr. Stewart: Just fussy. No, but just fussy and so I’ve always warned…

Kara Stewart-Mullens: Yeah.

Dr. Stewart: People when you start this, if you see, some emotionality, that’s actually a good sign because what’s happening is you’re making more energy, your brain’s not used to it and it’s got to readjust.

Kara Stewart-Mullens: Boy it sounds like the methylation thing…

Dr. Stewart: Same stuff.

Kara Stewart-Mullens: Sometimes when you start methylation, you say it’s like drinking a cup of coffee and your body goes into this, overload because it’s not used to having it. It’s kind of the same concept?

Dr. Stewart: So the whole idea is, we now know, and I reinforce this with all my patients very repetitively…

Kara Stewart-Mullens: Okay. Everyday.

Dr. Stewart: You know, every time I see them, is you got to have methylation, you got to have energy.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Detoxification is another issue because if you don’t detox well, you start to poison these mitochondria.

Kara Stewart-Mullens: And that’s what the glutathione issue.

Dr. Stewart: That’s with glutathione.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So, you know, the problem is too, is that we’re learning that a lot of the things we use medicinally…

Kara Stewart-Mullens: Yeah and we’re going to talk about that on part two of this, but go ahead and touch on it.

Dr. Stewart: A lot of what we’re learning in a lot of the literature now that certain pharmaceutical drugs poison mitochondria.

Kara Stewart-Mullens: Really? So if you keep feeding that pharmaceutical drug it’s going to break them down?

Dr. Stewart: So you can just say drugs that poison mitochondria and start reading. You’ll be shocked.

Kara Stewart-Mullens: Oh gosh. Wow. I guess everybody’s going to jump on Google. I recently found that a lot of your patients do have that issue in the beginning of being overloaded.

Dr. Stewart: Sure.

Kara Stewart-Mullens: If someone does start to take something for support that you mentioned, do they need to slow down?

Dr. Stewart: Yeah. Sure.

Kara Stewart-Mullens: Down to one capsule instead of two?

Dr. Stewart: Yeah and so we made it in a two capsule dose for the new Mito Cell PQQ.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Which is perfect because a lot of people have to start with half the dose.

Kara Stewart-Mullens: Just like sometimes with methylation?

Dr. Stewart: That’s correct.

Kara Stewart-Mullens: Okay.

Dr. Stewart: So you always work into it because there’s no reason for you to suffer. A lot of people are like I’m fine. I’m going to suffer through it and I’m like but your family isn’t going to be happy.

Kara Stewart-Mullens: Yeah. Exactly (laughing). You’re going to bite my head off.

Dr. Stewart: Yeah. So let’s just take our time and obviously some people are more sensitive than others. The more severe your weakness, the more overloaded your brain gets with this newfound energy.

Kara Stewart-Mullens: Okay. Now and this leads me to my next question. So you don’t always start out with the mitochondrial issue. It can happen later in life because you always kept talking about triggering events.

Dr. Stewart: Yeah. So triggering events basically put pressure of increased energy need on some other area. So if let’s say you get sick.

Kara Stewart-Mullens: Yep.

Dr. Stewart: And your immune system revs up and steals all the energy. How good does your brain work when you’re sick?

Kara Stewart-Mullens: Not very well.

Dr. Stewart: Right. Okay. How strong are your muscles when you’re sick?

Kara Stewart-Mullens: Not very strong.

Dr. Stewart: Exactly. So the body shunts energy where it needs it.

Kara Stewart-Mullens: Okay.

Dr. Stewart: Now the whole idea is we’re supposed to have adequate energy for everything to go on at the same time. Okay? But if we don’t have that and we’re limited, we will isolate the energy where we need it.

Kara Stewart-Mullens: Okay.

Dr. Stewart: From a conceptual standpoint. Now there’s biochemical aspects to that too. But basically you always want to have enough energy to where your brain works, the majority of the days, well. Your immune system works well because you’re looking at cancer, cancer appears to be a mitochondrial weakness.

Kara Stewart-Mullens: Really? You mean during cancer or…

Dr. Stewart: No, I’m talking about cancer but also the drugs we use to kill cancers can poison mitochondria too.

Kara Stewart-Mullens: Oh gosh that’s horrible.

Dr. Stewart: Understand?

Kara Stewart-Mullens: Yeah. So that’s why…

Dr. Stewart: So the whole idea is…

Kara Stewart-Mullens: You can’t recover?

Dr. Stewart: What are we really doing here biochemically? Now I’m not going to…

Kara Stewart-Mullens: You’re going to start a big controversy here.

Dr. Stewart: Well…

Kara Stewart-Mullens: But you have proof?

Dr. Stewart: I’m not the guy starting it.

Kara Stewart-Mullens: Oh. It’s already been in the literature…

Dr. Stewart: It’s already out.

Kara Stewart-Mullens: For a long time.

Dr. Stewart: Okay. And the NIH has lots of papers…

Kara Stewart-Mullens: Yeah.

Dr. Stewart: On drugs that poison mitochondria.

Kara Stewart-Mullens: Wow. And I know you’re speaking on this at the World Congress…

Dr. Stewart: Yes I am.

Kara Stewart-Mullens: Of anti-aging in December.

Dr. Stewart: Correct.

Kara Stewart-Mullens: So he’ll be in Vegas if anybody wants to make it out who’s a medical professional…

Dr. Stewart: And I’m not trying to criticize. What I’m telling you is if we sit stagnant and we think we’ve got everything licked, I will promise you that you haven’t.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: We’ve got to always be learning, always got to know what’s going on, always got to take the next step in objectivity and that’s why I’m so excited about genetics because all this chemistry that nobody really understood what the heck I was talking about…

Kara Stewart-Mullens: Yeah.

Dr. Stewart: All of a sudden, it got proven and then we learn there was a whole lot more to it.

Kara Stewart-Mullens: Yeah.

Dr. Stewart: Than we even thought, which is really exciting.

Kara Stewart-Mullens: Well that’s why I always like doing the show with you because you always have something new to say. I’m like oh my gosh, I didn’t know that and I can’t wait to hear you speak in December. So, you know what, with that, we’re going to have a wrap. Again we ran out of time, but…

Dr. Stewart: Sure.

Kara Stewart-Mullens: On the next episode, I want to talk about those drugs you were talking about.

Dr. Stewart: Okay.

Kara Stewart-Mullens: In particular, like what kind of drugs because everybody’s going to wonder about that.

Dr. Stewart: Sure they are.

Kara Stewart-Mullens: They can go to Google and find out, but maybe we could get a little more information from you and then I still want to talk about some issues that happen later in life and what we can do to avoid it.

Dr. Stewart: Sure.

Kara Stewart-Mullens: Or we can get to recover from it. So with that, ladies and gentlemen, I thank you so much for joining us today on episode ten and we hope that you have a beautiful and blessed Sunday.

This show is intended for general information and entertainment purposes only. Dr. Stewart serves as the chief science officer and lead formulator for Neurobiologix and advises you to consult with your own medical professional on any information given during this programming. This information is not intended to diagnose, treat, or cure any disease or medical condition.