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GAD Mutations: The Link to Depression, Anxiety, and Sleep Problems

Coffee With Dr. Stewart Podcast Season 4 - Episode 2
Podcast Show Date: December 18, 2017

In this episode, we discuss with Dr. Stewart how GAD mutations affect people today including their mood, sleep, and overall well-being, and how a person can overcome this mutation nutritionally.

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Kara Stewart-Mullens: Welcome to Coffee With Dr. Stewart. I am your host Kara Stewart-Mullens and this show is to provide our listeners with up to date medical information from a leading neurotologist and nutrigenomic specialist. I invite you to sit back, grab your favorite beverage or cup of coffee and let’s have Coffee with Dr. Stewart.

Good afternoon everybody. Welcome to Coffee with Dr. Stewart. I am your host Kara Stewart-Mullens and we are on season 4 and this is episode 2. I’m super excited to be here today because this is a great topic. It’s probably not a very common topic, but you know how Dr. Stewart and I like to roll out some very uncommon topics and then bring a lot of light to them, but we’re going to be talking about GAD. He’s going to explain it; everything. Hi, Dr. Stewart, how are you?

Dr. Kendal Stewart: (laughing)…

Kara Stewart-Mullens: His eyes are like rolling everywhere going, “Oh gosh, here we go…”

Dr. Kendal Stewart: Oh my GAD, right.

Kara Stewart-Mullens: Oh my GAD! So GAD, everybody, is spelled G-A-D.

Dr. Kendal Stewart: Yeah. What is stands for is glutamic acid decarboxylase.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: It’s a mutation that is…

Kara Stewart-Mullens: Genetic mutation?

Dr. Kendal Stewart: It’s a genetic mutation that is actually, turned out to be, way more common than we even expected and plays so many different roles in symptomatic control, ADD, anxiety, stress…

Kara Stewart-Mullens: Sleep problems…

Dr. Kendal Stewart: Brain dysfunction, lots of problems that I think it’s going to be one of the most important things that you’ll be able to know about.

Kara Stewart-Mullens: Well and when we talked, you know, we can do a whole show on GAD.

Dr. Kendal Stewart: Oh, we can do a couple of them.

Kara Stewart-Mullens: A couple of shows on GAD because there’s just…it’s pain, it’s dysphoria, explain dysphoria, what people with GAD mutations.

Dr. Kendal Stewart: Well let’s just talk about GAD up front, okay?

Kara Stewart-Mullens: Okay. Alright.

Dr. Kendal Stewart: Now as with all enzymes, you have to understand what the heck they do; especially if you’re looking at genetics. Now the most prevalent neurotransmitter in our brain is a neurotransmitter called glutamate.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: And glutamate is a stimulant and everybody’s heard of MSG so MSG is monosodium glutamate and what most people don’t understand is we have more glutamate in our brain than anything. And so what the GAD mutation, especially GAD1, glutamic acid decarboxylase, it takes glutamate and converts approximately 40% of it to GABA.

Kara Stewart-Mullens: The good stuff.

Dr. Kendal Stewart: And GABA is…

Kara Stewart-Mullens: Makes you feel good.

Dr. Kendal Stewart: Gamma-Aminobutyric Acid so it’s a mneumonic.

Kara Stewart-Mullens: And it calms us down…

Dr. Kendal Stewart: And what GABA does is GABA is a calming agent for the nervous system, but it’s also used to initiate sleep, to calm your nervous system, to essentially give you a state of euphoria or you feel content…

Kara Stewart-Mullens: Okay. I like that.

Dr. Kendal Stewart: Not happy, but content. It also is used in lots of hormonal regulation processes and in general, what the body is designed to do in a perfect scenario is have a perfect balance between stimulation and calming.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Because the way God built our nervous system in particular is it’s too hard to go from off to on, from a physiologic standpoint. It takes too much time. So what God does with our nervous system is He has kind of a resting rate; it’s always on and we either turn it up or we turn it down.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Because it’s really easy to turn it up and down if it’s always on. And so the problem is if we have a lot of glutamate turning it on all the time, the problem is glutamate, not only tells the nervous system, but also the body in general, to actually increase its metabolic rate, it causes the brain to overstress itself. And so we see, in particular, a very large amount of glutamate flooding the system in times in crisis.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Now the most easily to understand one is following a head injury. Has anybody ever understood why you bang your head and even if you don’t get a bleed or a bruise or something on the brain, why do you get dingy?

Kara Stewart-Mullens: And no one…nothing shows up on your MRI?

Dr. Kendal Stewart: No, and nothing shows up on your MRI. Well it’s because we get what we call a glutamate storm.

Kara Stewart-Mullens: Oh, like a flood?

Dr. Kendal Stewart: You get a flood. And so what happens is once we get a head injury, in theory, back to the woods…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Once we got a head injury, we may be a little easier target for the bears, so God floods glutamate into our brain to make us more aware, increase our metabolic rate, turn up our anxiety, turn up our awareness.

Kara Stewart-Mullens: So the brain injury, we’re not in the woods, so it doesn’t do us good because we’re in an over-excitatory state?

Dr. Kendal Stewart: That’s correct. And so, in general, if you really want to understand concussions, which we’ll talk about at a certain point in time, we got to understand that glutamate plays a huge role. Now if you’re a person who has more glutamate than GABA, those are the people who do very poorly from head injuries, for instance.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Okay? Now the second thing that’s really important is that we have now recognized which is not written and I’m sure I’m going to get some calls about it…

Kara Stewart-Mullens: You’re going to do a white paper (laughing)…

Dr. Kendal Stewart: We have actually recognized two forms of ADD.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Okay? Now typically ADHD is a dopamine deficiency and those are the kids that are running around like crazies…

Kara Stewart-Mullens: Hyper…

Dr. Kendal Stewart: You understand? Hyper, really and completely out of it and that’s dopamine deficiency and that’s what we classically give stimulants for…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Ritalin and Adderall or we give them Methylation, etc., but this whole scenario, there are lots of people who, once they get put on stimulants, they do poorly.

Kara Stewart-Mullens: Right. It has the opposite effect.

Dr. Kendal Stewart: They don’t do well. Well what those people actually have is a glutamate/GABA imbalance.

Kara Stewart-Mullens: Oh. Because they have a GAD mutation?

Dr. Kendal Stewart: Okay? So they have a GAD mutation and so what we essentially have is too much glutamate in the brain and what the brain does is it runs at such a high level that it can’t keep up with its nutritional needs and it essentially wears out about noon every day.

Kara Stewart-Mullens: And would these also be the people, because it is so high glutamate has been shown to cause, anxiety of course…

Dr. Kendal Stewart: Sure.

Kara Stewart-Mullens: But bipolar, OCD, and bedwetting?

Dr. Kendal Stewart: Sure. Yeah, but what we call this form of ADD is inattentive or unfocused ADD.

Kara Stewart-Mullens: And what would a person appear like if…

Dr. Kendal Stewart: Unfocused.

Kara Stewart-Mullens: Oh.

Dr. Kendal Stewart: So here’s what happens…my child really has a problem. He’s not hyperactive, he’s just got problems with focus.

Kara Stewart-Mullens: Right. Oh! That just…

Dr. Kendal Stewart: Just focus.

Kara Stewart-Mullens: So why have they kind of taken away the term ADD and now they all call it ADHD?

Dr. Kendal Stewart: Well it’s because they’re trying to get it labeled and on a drug.

Kara Stewart-Mullens: The hyperactive…but the hyperactivity isn’t always there.

Dr. Kendal Stewart: No. You’ve got to understand that when they prescribe drugs, a lot of times, they have to have specific diagnoses to prescribe the drug.

Kara Stewart-Mullens: Right. So would this back to just typical ADD, like without the…

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: Hyperactive?

Dr. Kendal Stewart: That’s correct. And so…

Kara Stewart-Mullens: Interesting.

Dr. Kendal Stewart: The treatment is completely different than the way you treat true ADHD.

Kara Stewart-Mullens: And what would the treatment be?

Dr. Kendal Stewart: Okay so in this scenario, where you’ve actually got too much glutamate and not enough GABA, we really want to lower the glutamate, we want to increase the GABA. Here’s the problem. And you can’t give GABA because GABA itself breaks down the glutamate.

Kara Stewart-Mullens: Ah because they have the mutation?

Dr. Kendal Stewart: Okay? So everybody thinks oh we’ll just give GABA. Well the problem is, no it’s not from the mutation, the natural course of GABA breakdown is back to glutamate, but if you can’t put it back to GABA, you wind up increasing the glutamate which was already a problem.

Kara Stewart-Mullens: Okay. Explain real quick what the path that GABA takes into the system or…

Dr. Kendal Stewart: So glutamate, converted by GAD1 to GABA so there’s supposed to be a perfect balance. The problem is if you give regular GABA, it’s going to break down to glutamate.

Kara Stewart-Mullens: And stay glutamate?

Dr. Kendal Stewart: And stay in glutamate.

Kara Stewart-Mullens: It won’t convert back to GABA?

Dr. Kendal Stewart: Not very well because that’s the problem in the first place.

Kara Stewart-Mullens: Ah…

Dr. Kendal Stewart: Now the way we’ve actually solved it is that we tend to use things to actually block the glutamate receptors. So the glutamate receptor is a receptor called the NMDA receptor.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Okay? And so that receptor is actually, there’s been lots of things that have been developed over long periods of time and there’s natural things than can help it. The things that are natural that helps it is elderberry extract, Sambuca, okay?

Kara Stewart-Mullens: Sambuca the Greek-like liqueur?

Dr. Kendal Stewart: Yeah. There’s a little berry…yeah, well that’s made from those berries.

Kara Stewart-Mullens: Right, right.

Dr. Kendal Stewart: You understand? I wouldn’t say give liqueur to…

Kara Stewart-Mullens: It tastes terrible, but (laughing)…

Dr. Kendal Stewart: Yeah. But Sambuca and so anise, a little bit does it too. Anise, the spice. So you may be a person who likes chai teas, you may be a person who likes pho at the Thai restaurants…

Kara Stewart-Mullens: I love pho! Is that because I’m deficient?

Dr. Kendal Stewart: No, you’re too much, you’re blocking the glutamate. So you’re a glutamate over stimulator.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: Now what we use medication wise is we love…I love medicines from the 70s.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: And the reason I tend to love them is because they come from plants usually.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: So anise was developed into a drug called Amantadine and Amantadine also has Namenda which is the new form of it, but amantadine is actually…was originally came out as an anti-flu drug.

Kara Stewart-Mullens: It’s an anti-viral, right?

Dr. Kendal Stewart: Well, it’s not really an anti-viral. What is does is it blocks the glutamate receptor and that’s where influenza loves to attack the cells. And so what Amantadine does is it tends to calm these kids down and so you reduce the glutamate.

Kara Stewart-Mullens: And this is a prescription?

Dr. Kendal Stewart: That’s a prescription, but you can use elderberry or Sambuca or things like that.

Kara Stewart-Mullens: Or the things we’re going to talk about in your new formula?

Dr. Kendal Stewart: Right. Now what also happens in about the new formula, is there’s a culture that we’ve actually found who has GAD1s quite a bit. Do you know what culture that is?

Kara Stewart-Mullens: Well I know because you told me and you said it in your workshop to a bunch of doctors, the Russians.

Dr. Kendal Stewart: The Russians. So Eastern Europeans have this tremendously well and the problem with having this is that you’re always in need of trying to calm the brain down. So if you have this GAD1 mutation, what people do if they don’t see doctors and you don’t help them, is they always go through the things that naturally calm the brain and that’s alcohol and marijuana.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: So I will tell you every alcoholic and I will tell you every kid who says he has to smoke weed…

Kara Stewart-Mullens: Has a GAD1 mutation?

Dr. Kendal Stewart: Has a GAD mutation. Every time. You won’t even have to guess.

Kara Stewart-Mullens: Ah. Interesting.

Dr. Kendal Stewart: You understand? Now they created a form of GABA in Russia. It’s called beta-Phenyl GABA.

Kara Stewart-Mullens: But it’s not like the traditional GABA?

Dr. Kendal Stewart: It’s a GABA that’s like that, but it’s chemically modified so it does not break down to glutamate and so that’s what we use for our new formula.

Kara Stewart-Mullens: Well I’ve been taking it and I feel really good. I take it in the morning, but I know a lot of people take it at night to wind down.

Dr. Kendal Stewart: Sure. Sure they do.

Kara Stewart-Mullens: And so why does one work for me in the morning and the others at night?

Dr. Kendal Stewart: Well it’s because you need help all day. You have a GABA imbalance, you don’t have enough GABA to keep your brain working at the right pace.

Kara Stewart-Mullens: Right. And I don’t have a double mutation?

Dr. Kendal Stewart: Just a single.

Kara Stewart-Mullens: Just a single? But that’s enough…

Dr. Kendal Stewart: If you have a double, then those people can’t go to sleep at night. They tell me their brain races down 4 or 5 different thoughts and they can’t finish one.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Their muscles stay more tense because GABA relaxes muscles.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: They tend to be much more sensitive to pain. They tend to be much more sensitive to anxiety and so their body’s just in this hypersensitive state so they’re always looking for something to kind of calm it down.

Kara Stewart-Mullens: Okay. And so do you think that’s where a lot of people look for things, like in alcohol and drugs and other things?

Dr. Kendal Stewart: Absolutely.

Kara Stewart-Mullens: So if we could get them nutritionally what they need….. A lot of people always say, “What does Dr. Stewart think about, you know, ex-alcoholics or people that have quit drinking or quit drug use…”

Dr. Kendal Stewart: Sure.

Kara Stewart-Mullens: They always look to focus on neurotransmitters.

Dr. Kendal Stewart: Well this is a neurotransmitter.

Kara Stewart-Mullens: Oh it is? Well explain that.

Dr. Kendal Stewart: Glutamate is a neurotransmitter.

Kara Stewart-Mullens: See I don’t know these things. This is all new to me. This is brand new.

Dr. Kendal Stewart: These are just standard neurotransmitters…

Kara Stewart-Mullens: I’m telling you, I looked last night, as I do before every show to try and prepare questions for this and there is not anything out there. You’ve got to write a paper on it and get it out there.

Dr. Kendal Stewart: Okay.

Kara Stewart-Mullens: You know, because people are suffering from depression, anxiety and they’re trying all these different things and if they just maybe looked at their GAD mutations, it would answer a lot of questions.

Dr. Kendal Stewart: Well you never can look at anything in isolation.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: So if you’re looking at serotonin and dopamine, you also got to look at GABA.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: It’s really the way God designed you to be a calm, content, processing, everything is great, is good dopamine, good serotonin, and good GABA.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: And that’s the way the world works.

Kara Stewart-Mullens: But if you have a GAD mutation?

Dr. Kendal Stewart: You’re not going to make enough GABA so you’re going to be in a hyper stimulated…

Kara Stewart-Mullens: Yeah. Because it says the, when GABA levels are depleted, this could lead to an excitatory state, causing anxiety, panic disorders, ADD of course, and be a contributory factor for chronic pain syndrome.

Dr. Kendal Stewart: Absolutely.

Kara Stewart-Mullens: So it manifests into a pain syndrome that maybe we never had an injury or how does that work?

Dr. Kendal Stewart: Well it just means that your nerves are in a hyper-excitable state and so they exaggerate everything that goes on. So if you’re supposed to have a little bit of pain, it’ll be a lot more…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: If you have more glutamate.

Kara Stewart-Mullens: And you know what? I know I have one copy, but sometimes pain is worse than others and is just because it’s a stressful time like in our last show that we talked about?

Dr. Kendal Stewart: Absolutely.

Kara Stewart-Mullens: Pain seems so much more severe.

Dr. Kendal Stewart: Absolutely.

Kara Stewart-Mullens: Well we’re going to take a break real quick and when we come back, I want to talk to Dr. Stewart about this new formula, Pro GAD Enhancer and then I want to talk to you about diet associated with people that have these double GAD mutations or have GAD mutations. So we’ll be right back with Coffee with Dr. Stewart.


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Kara Stewart-Mullens: Alright everybody, welcome back to Coffee with Dr. Stewart. We are on season 4, episode 2 talking about GAD, G-A-D. GAD mutations, just to kind of recap, you can go back to some of our previous shows. Dr. Stewart is a genetic specialist, nutrigenomics, GAD is a serious mutation that a lot of people have out there that now that we’ve done so many genetic tests, how common is it, Dr. Stewart, would you say?

Dr. Kendal Stewart: Well I mean, it depends on your race, but if you’re a white person, I’d say probably 70%.

Kara Stewart-Mullens: Really?

Dr. Kendal Stewart: Mmm-hmm, 60.

Kara Stewart-Mullens: And depression rates are higher typically and when you say, you know, like…

Dr. Kendal Stewart: The depression is higher because you’re stimulating the brain to overwork itself. Remember depression is a depletion of neurotransmitters, you’ve overworked the brain.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Whether it’s by stress or a challenging event or a neurotransmitter imbalance, what you’ve just done is you’ve worn the brain out.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: You can’t keep up with anything and that’s why those people are so miserable, because their brain is just…

Kara Stewart-Mullens: …it’s done.

Dr. Kendal Stewart: It’s done.

Kara Stewart-Mullens: And they can’t get out of it.

Dr. Kendal Stewart: That’s right.

Kara Stewart-Mullens: So could…

Dr. Kendal Stewart: So people with GAD, who run at a higher metabolic rate, just like driving your car faster, you run out of resources quicker.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: And so that’s the problem. That’s why GAD contributes to this and it also turns up the sensitivity of the entire system so it becomes a bigger deal when you have more glutamate.

Kara Stewart-Mullens: Well in the beginning of this year, 2017, you did your advanced genetic workshop and you said, in front of everybody, “I’m going to figure this dang GAD issue out.” Because you were stumped because a lot of people hadn’t figured out what to do about a GAD mutation, but we knew it was affecting people that have it tremendously, you know, with how they feel about themselves, with the dysphoria that you talk about…

Dr. Kendal Stewart: Right.

Kara Stewart-Mullens: And so you’ve came with something. You came out with the Pro GAD Enhancer and I mean it’s amazing. I mean great feedback and myself, I love it.

Dr. Kendal Stewart: Yeah. What we did is we took that form of GABA I mentioned before, beta-Phenyl GABA and if you start looking at the…

Kara Stewart-Mullens: That’s phenibut?

Dr. Kendal Stewart: That’s phenibut.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: If we look at the receptor, we find out that glycine basically is the opposite of glutamate.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: So we use some glycine. Magnesium and zinc helped and then we also had NAC and then there’s also a scavenger that we’re probably going to wind up putting in the formula eventually and it’s called oxaloacetate.

Kara Stewart-Mullens: And what does that do?

Dr. Kendal Stewart: It scavenges…they call it a…

Kara Stewart-Mullens: I like the word scavenge (laughing).

Dr. Kendal Stewart: It’s a glutamate scavenger.

Kara Stewart-Mullens: What does scavengers do?

Dr. Kendal Stewart: This means it grabs it. It doesn’t let…

Kara Stewart-Mullens: Oh okay. Eats it up?

Dr. Kendal Stewart: Yeah, eats it up. And so the problem is you would have these groups of people who we’d say, “Oh you got a GAD1, take some GABA,” and they’d take GABA and they’d go through the roof.

Kara Stewart-Mullens: Right. I wanted to ask you about that.

Dr. Kendal Stewart: Okay? And so what was happening in that scenario is that we have a significant problem with the GABA breaking back down to glutamate and not being able to produce more GABA.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Now that also happens in another group of patients. Glutamine which is a precursor to glutamate is used in the bowel and it actually works very well for a lot of people in their bowel.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Okay? Because it helps motility and everything else, but the problem is, is that if you put glutamine in and you look at the bowel in isolation, you’ll have a lot of people that get whacked out…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: In their brain when they put them on glutamine. So we have to be really…

Kara Stewart-Mullens: Became excitatory…

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: And kind of euphoric.

Dr. Kendal Stewart: Mmm-hmm. And so what happened is we’ve got to be real careful in understanding and making sure we stay holistic and we’re looking at the whole body instead of looking at individual organ systems…

Kara Stewart-Mullens: And that’s a problem. A lot of people go, “Oh the brain, oh the gut,” no everything is connected.

Dr. Kendal Stewart: Well here’s the reason the gut and the brain tend to be talked to together because they’re using the same neurotransmitters.

Kara Stewart-Mullens: Oh.

Dr. Kendal Stewart: Okay? It doesn’t mean that they are connected, but they use the same neurotransmitters…

Kara Stewart-Mullens: They require all the neurotransmitters?

Dr. Kendal Stewart: Mmm-hmm.

Kara Stewart-Mullens: Well here’s the interesting…so when we came out with this formula a few months ago, you know, you see phenibut on the label and people are like, “Oh I’m going to go and look up phenibut,” of course. There’s other cofactors and if you read about phenibut, you know, they were using them in high doses, people were…

Dr. Kendal Stewart: Sure.

Kara Stewart-Mullens: It could have an addictive property to it and then you have to take more and more and more. But you explained in your workshop how it works as the glycine as the buffer.

Dr. Kendal Stewart: Right. So the thing is, is what you never want to do is depend on one agent to manipulate the system.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Okay? And that’s kind of the problem with drugs. You’re going to see the newest rage in drugs is let’s put two or three drugs together and then get them patented. Okay?

Kara Stewart-Mullens: Uh-huh. Oh look, they’ve followed what you do (laughing).

Dr. Kendal Stewart: Yeah. So the thing is you never want to use one agent in too much concentration and that’s what phenibut was doing. Okay?

Kara Stewart-Mullens: By itself?

Dr. Kendal Stewart: If you’re a person who is an alcoholic or you had a drug use, I mean you’ve had to take a tremendous amount of phenibut to really get the effect of what you were doing there.

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: So what we had to do is we had to add in other ways to manipulate the receptor and to make the nervous system calm down and that makes us not to have to use so much phenibut, but we still get the same effects.

Kara Stewart-Mullens: Because you got 300 milligrams of phenibut, but then you have…I can’t remember how much glycine, but you say that’s what kind of buffers the need for more…

Dr. Kendal Stewart: It does buffer it, but…

Kara Stewart-Mullens: And more and more…

Dr. Kendal Stewart: It also helps…that’s exactly right. It just keeps everything in a balance and what we actually did is we took about 50 patients and, who had GAD1 double copies, and what we did is we gave them each of those individually.

Kara Stewart-Mullens: Okay.

Dr. Kendal Stewart: And we asked them to call us back at 4 weeks and 8 weeks and let us know how they liked it. And so that’s how we decided we would build that formula because it worked for people.

Kara Stewart-Mullens: Right. And what’s interesting, like I said, you know, for me, it’s…I like it in the morning. I’m not a double GAD…

Dr. Kendal Stewart: Right.

Kara Stewart-Mullens: But I like it in the morning because it makes me feel kind of…a little euphoric…

Dr. Kendal Stewart: Right.

Kara Stewart-Mullens: But a couple of my employees take it in the evening because they can’t turn their brains off.

Dr. Kendal Stewart: Yeah. I tell people to…

Kara Stewart-Mullens: It helps them sleep.

Dr. Kendal Stewart: It’s not a sleep agent.

Kara Stewart-Mullens: No, it is not.

Dr. Kendal Stewart: It’s a wind your brain down so you can go to sleep agent.

Kara Stewart-Mullens: We should have called it wind your brain down.

Dr. Kendal Stewart: Yeah.

Kara Stewart-Mullens: Because, see, I wake up with my brain going a million miles a minute.

Dr. Kendal Stewart: Yeah. You know I wanted to call it oh my GAD…

Kara Stewart-Mullens: Oh my GAD because it helps you so much (laughing). I wouldn’t let you put that on the label (laughing). I don’t know if you think I ever will.

Dr. Kendal Stewart: That’s what I wanted to call it.

Kara Stewart-Mullens: Yeah. Well let me ask you this. So, you know, we have our Calming Cream and we have our Mood Plus, both have GABA in it and many years ago…

Dr. Kendal Stewart: Yeah.

Kara Stewart-Mullens: People would take it, now it worked for a lot of people, but then you’d have these kids or parents or just people that say oh my God, no, it keeps me awake…

Dr. Kendal Stewart: Sure.

Kara Stewart-Mullens: It doesn’t do anything for me and we always wondered why.

Dr. Kendal Stewart: That’s these people.

Kara Stewart-Mullens: That have GAD mutations?

Dr. Kendal Stewart: Yep.

Kara Stewart-Mullens: So what’s happening when they’re taking it? Is it…

Dr. Kendal Stewart: Well it’s got GABA in it, so they’re producing more glutamate.

Kara Stewart-Mullens: Oh man. So we would just tell them to stop taking it, it’s obviously not the right product for you.

Dr. Kendal Stewart: It’s not the right product for them.

Kara Stewart-Mullens: But with the genetics now, we have proof.

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: So what would you recommend for a patient that, you know, I guess you could go out and do a GABA test, GABA is very inexpensive. You could go out and take some GABA and see what happens to you. If it gives you an excitatory state and not a calming state, would you want to get your genetics done to see where it’s at?

Dr. Kendal Stewart: I’m always, you know…

Kara Stewart-Mullens: I know. You want everybody to have a genetic test in the entire world and I think they should too.

Dr. Kendal Stewart: Of course. Absolutely.

Kara Stewart-Mullens: And it may be that way one day.

Dr. Kendal Stewart: Well it’ll wind up saving you money and hassle and effort and everything else.

Kara Stewart-Mullens: That is true. That is true.

Dr. Kendal Stewart: Okay? We’ve just got to get it…

Kara Stewart-Mullens: But let’s say you don’t have the money to go get your genetic test, even though it’s becoming very, very reasonable…

Dr. Kendal Stewart: Well…

Kara Stewart-Mullens: Yeah, so would you go take some GABA and see how it affects you?

Dr. Kendal Stewart: Sure you can.

Kara Stewart-Mullens: And then you can go okay, well, I need to stay away from things that have GABA in it and look to other sources…

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: That can help glutamate.

Dr. Kendal Stewart: Right. You can pretty much tell…

Kara Stewart-Mullens: Not take…

Dr. Kendal Stewart: By symptoms, though. You don’t even have to do that. If you have trouble turning your brain off, if your muscles stay tighter, if you have low blood pressure, if you have constipation. Remember GABA relaxes muscles so people…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: With constipation chronically can’t relax the bowel so it can squeeze back, well that’s called peristalsis…

Kara Stewart-Mullens: I knew there was a big word for that, yeah.

Dr. Kendal Stewart: Right? People who have a tiny bladder syndrome.

Kara Stewart-Mullens: Right? Oh.

Dr. Kendal Stewart: Women with IC.

Kara Stewart-Mullens: You mean people that have to pee a lot like men?

Dr. Kendal Stewart: They can’t relax…

Kara Stewart-Mullens: Especially they always think it’s their prostate, but it may not be that?

Dr. Kendal Stewart: They can’t relax their bladder. Women with interstitial cystitis, if you have chronic pain syndromes, if you have inattentive ADD; those are all GAD.

Kara Stewart-Mullens: So this is why they talked about the overstimulation of glutamate for bed wetting?

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: Because they can’t…

Dr. Kendal Stewart: They can’t relax their bladder.

Kara Stewart-Mullens: They can’t relax their bladder in that sleep state that you talk about?

Dr. Kendal Stewart: Correct.

Kara Stewart-Mullens: Oh my gosh. A light bulb just…

Dr. Kendal Stewart: Good.

Kara Stewart-Mullens: Popped over my head.

Dr. Kendal Stewart: Finally.

Kara Stewart-Mullens: Three times (laughing). Thank you. That’s so nice. Okay well let’s get to this. So diet? What do you think about diet for people that have GAD mutations?

Dr. Kendal Stewart: Well, the thing is there are certain glutamate stimulators and the most notorious is actually sugar. Has anybody ever…

Kara Stewart-Mullens: Sugar.

Dr. Kendal Stewart: Wondered why you give a class of third graders cupcakes and then everybody goes nuts?

Kara Stewart-Mullens: But everybody thinks it’s like; I have a 9-year-old and they’re like, “Oh you give them sugar and you’re wound up,” and you used to think that people were just saying that, but it’s the sugar turning to glutamate.

Dr. Kendal Stewart: Nope. Not turning to it, it just stimulates glutamate.

Kara Stewart-Mullens: Oh, okay. So it is a true statement then?

Dr. Kendal Stewart: That’s right. And the kids that get really wound up, those kids have GAD.

Kara Stewart-Mullens: Hmm. Interesting. Yeah, my 9-year-old, yeah, trying to fight the sugar, it’s hard.

Dr. Kendal Stewart: Don’t you like MSG in your food?

Kara Stewart-Mullens: I hope it doesn’t have MSG in it.

Dr. Kendal Stewart: No. But what I’m telling you is the reason food tastes better is because you stimulate your brain…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: When you have MSG and so that Chinese food tastes extra good.

Kara Stewart-Mullens: But now, you know, remember a big marketing plan went out 10 years ago that took out all the MSG from Chinese food?

Dr. Kendal Stewart: Right.

Kara Stewart-Mullens: You know, so it’s MSG free, MSG free. Was that because they were getting some negative effects?

Dr. Kendal Stewart: Well it’s just because if you have a GAD and you take MSG, it’s going to really affect you.

Kara Stewart-Mullens: Okay. So other than the Pro GAD…

Dr. Kendal Stewart: MSG is still really prevalent.

Kara Stewart-Mullens: Right. We just don’t know about it (laughing).

Dr. Kendal Stewart: You know, a classic thing is, you know that meat tenderizer or…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Seasoning salts for your steaks and stuff?

Kara Stewart-Mullens: MSG?

Dr. Kendal Stewart: Turn it over.

Kara Stewart-Mullens: That’s why I love all the steaks. So what will be listed on the back of label?

Dr. Kendal Stewart: A lot of times they’ll spell it out monosodium glutamate so you don’t…

Kara Stewart-Mullens: So you don’t recognize it?

Dr. Kendal Stewart: Recognize it.

Kara Stewart-Mullens: Very interesting. I might have to go up and look. So soy sauce and things like that you…

Dr. Kendal Stewart: Sometimes.

Kara Stewart-Mullens: You want to just look at the back of the label?

Dr. Kendal Stewart: Well, you know, especially if you have a GAD.

Kara Stewart-Mullens: The little that I found on the internet about these mutations, the paleo diet was recommended, why is that? Because a lot of our products are paleo friendly.

Dr. Kendal Stewart: Well paleo is very sugar unfriendly.

Kara Stewart-Mullens: Oh, okay.

Dr. Kendal Stewart: Do you understand? Paleo is just a good thing anyway.

Kara Stewart-Mullens: It is.

Dr. Kendal Stewart: For most people.

Kara Stewart-Mullens: And why is that?

Dr. Kendal Stewart: It’s just you stay away from most of the inflammatory foods and you’re eating more like your ancestors did.

Kara Stewart-Mullens: Back in the like caveman days?

Dr. Kendal Stewart: Not caveman. I mean if you look at ancient cultures, if you go back 500 years and look at the cultures, everybody was eating fruits and vegetables, seasonal fruits, vegetables…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Meats and that’s pretty much all you ate.

Kara Stewart-Mullens: What was grown in your garden, what you got off the cow, right? Or the pig?

Dr. Kendal Stewart: Right.

Kara Stewart-Mullens: So…

Dr. Kendal Stewart: Well you didn’t kill your cow, you didn’t eat the meat, you milked it.

Kara Stewart-Mullens: Oh. Okay (laughing). Alright (laughing). Well I’m just…

Dr. Kendal Stewart: You understand?

Kara Stewart-Mullens: Looking here, you know, the recommended reduced foods such as peas, tomato juice, parmesan.

Dr. Kendal Stewart: Okay. What he’s talking about there is that’s basically those are things that actually have histamine reactions or potential histamine reactions.

Kara Stewart-Mullens: Like you’ve talked about the dark tomatoes…

Dr. Kendal Stewart: And histamines can stimulate glutamate too.

Kara Stewart-Mullens: Okay. So would the GI Hist be…

Dr. Kendal Stewart: It can be. If you just stay away from it, you’ll be better.

Kara Stewart-Mullens: But the GI Hist, if you want to eat something with histamine and you have a GAD1, you could take the GI Hist…

Dr. Kendal Stewart: Sure you could.

Kara Stewart-Mullens: To kind of help…

Dr. Kendal Stewart: There’s no doubt about it.

Kara Stewart-Mullens: Okay. That’s very interesting. God, you don’t even realize what different things you can take out there to help with…

Dr. Kendal Stewart: Well and, you know…

Kara Stewart-Mullens: Types of reactions.

Dr. Kendal Stewart: The biggest thing with glutamate that’s become very popular in the media with too much glutamate is the chronic pain and the opiate.

Kara Stewart-Mullens: Right. We’re going to do a whole show on chronic pain. So…

Dr. Kendal Stewart: And the opiate addiction problem that we’ve got.

Kara Stewart-Mullens: Gosh, that’s all over the news everywhere. It’s terrible.

Dr. Kendal Stewart: Well it is. And so glutamate and GAD plays a big role in that too.

Kara Stewart-Mullens: And tell me a little bit about what the chronic pain with the GAD mutations. How…why is that so prevalent?

Dr. Kendal Stewart: Well the people who have the pain syndromes and they get over it and they get off their narcotics and they’re fine…

Kara Stewart-Mullens: Right.

Dr. Kendal Stewart: Are great, but the problem is when you have a GAD mutation and you have too much glutamate, your nervous system stays at a hypersensitive state so that small amount of pain becomes a big amount of pain to you.

Kara Stewart-Mullens: Oh. I got you. So then they think they need more medication?

Dr. Kendal Stewart: Chronic narcotics. They don’t think they need it, they do need it.

Kara Stewart-Mullens: They do need it?

Dr. Kendal Stewart: They do need it, but you’ve got to calm the glutamate down so that they don’t need it.

Kara Stewart-Mullens: And how can you do that? With the Pro GAD and phenibut…

Dr. Kendal Stewart: You can.

Kara Stewart-Mullens: Things of that nature?

Dr. Kendal Stewart: But then there’s also Ketamine and other things that we…

Kara Stewart-Mullens: That’s an IV drip?

Dr. Kendal Stewart: Yeah. That we’ll talk about.

Kara Stewart-Mullens: Yeah. And we’re going to have some doctors on that are pain specialists, they’re MDs, pain specialists that are going to come…I don’t know if you know this yet, but they’re going to come and do a show with us…

Dr. Kendal Stewart: Great.

Kara Stewart-Mullens: Next month, but I’m excited to have them on and so look forward to that. But I just want to wrap it up here. So if you take GABA, you have an issue, it makes you excitatory, that would be your first clue kind of ding, ding, ding.

Dr. Kendal Stewart: Yeah. But just go by the symptoms. You’ll know.

Kara Stewart-Mullens: Go by the symptoms?

Dr. Kendal Stewart: You can talk to somebody and know.

Kara Stewart-Mullens: And a lot of people that seem to be very sensitive and sad at times and the dysphoria that you talked about, don’t have a good sense of well-being?

Dr. Kendal Stewart: Sure. Can’t sleep. Have muscles that are tense.

Kara Stewart-Mullens: Yeah. But then I know some people that I know have double GADs that do exercise, get to sleep at the same time every night and they do very well.

Dr. Kendal Stewart: Sure.

Kara Stewart-Mullens: You know so it’s not hopeless. I don’t want anybody to think that we’re talking about this because it’s hopeless.

Dr. Kendal Stewart: No, it’s not hopeless.

Kara Stewart-Mullens: We’re here to guide you in what you can do about it. Right?

Dr. Kendal Stewart: Absolutely.

Kara Stewart-Mullens: Any other words of wisdom you’d like to…

Dr. Kendal Stewart: Well the people with double GADs, if you live a quality life and don’t have a lot of stressors and you exercise and take care of yourself, you’re going to do better.

Kara Stewart-Mullens: Alright. Well you heard it from the man there. Alright everybody. We want you to have a great day. You can call us at 866-500-5388 or submit questions to and everybody have a blessed and beautiful day.


The views expressed by show hosts or the guests are their own and shall not be construed in any way as advice in place of your own medical practitioners. We encourage you to seek professional advice or care for any problem which you may have.