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D-Chiro-Inositol (DCI)

DCI, D-Chiro-Inositol: Help for Poly Cystic Ovary Syndrome (PCOS), and Metabolic Syndrome Part 1

When insulin binds to its receptor on the cell, it “unlocks” and releases secondary messengers.There are two insulin mediators or messenger molecules – Myo-Inositol and D-Chiro-Inositol that let the cell know it needs to respond to insulin. Inositol-phospho-glycan,(IPG) cleaves to either myo-inositol or D-chiro-inositol. D-chiro-inositol, (DC-IPG), signals to the cell to either burn or store sugar. While Myo-IPG signals to produce testosterone.

So, when D-chiro inositol, DC-IPG signals the cell to either burn or store sugar, the sugar gets used and insulin is reduced, which triggers Myo-IPG to stop producing testosterone. But some people genetically cannot produce enough DC-IPG. Without enough DC-IPG telling the cells to dispose of sugar, it in turn keeps insulin high, AKA, insulin resistance, which doesn’t trigger Myo-IPG to stop producing testosterone, keeping it high. Women with Poly Cystic Ovary Syndrome, (PCOS), generally have an elevated testosterone due to her body’s inability to convert to DC-IPG.

A special note to you guys out there: this is only referring to testosterone secreted by the “theca” cells in the ovary not the testes. So, DCI will not effect your testosterone secretion.

Besides helping PCOS, inositol has many important benefits. Studies have shown that it reduces triglyceride levels, increases HDL (“good”) cholesterol, and decreases blood pressure. Inositol may also reduce the risk of type 2 diabetes and gestational diabetes, while it may improve the risk factors of metabolic syndrome. Infertility may be caused by hormonal imbalances. DCI has been shown to normalize menstrual cycles and help restore ovulation.

Another factor about Inositol is it functions as a secondary messenger for serotonin and dopamine, neurotransmitters that send signals back and forth between the brain and other systems in the body. Low levels of inositol may disrupt this signaling, possibly resulting in mood disorders and impaired mental health. So just to recap, research finds DCI has been shown to:

  • Increase cellular insulin sensitivity
  • Increase fertility
  • Improve ovulation frequency by 300%
  • Increase low progesterone levels
  • Reduce serum insulin levels
  • Reduce raised serum androgens (testosterone) both free and total
  • Reduce glycosylated hemoglobin (HbA1c) an indicator of long term sugar levels
  • Reduce plasma triglyceride levels (the amount of fat in your blood)
  • Reduce (bad) LDL cholesterol
  • Increase (good) HDL cholesterol
  • Reduce raised blood pressure, both systolic and diastolic

But wait that’s not all! See what else DCI is good for in Part 2. DCI, Gets the Good Housekeeping Seal of Efficiency!




DCI, D-Chiro-Inositol Gets the Good Housekeeping Seal of Efficiency! Part 2

Studies are now showing that D-Chiro-inositol, (DCI) increases autophagy. Autopha what???

Okay, here we go down the rabbit hole:

As a normal part of metabolic processes in the human body, cells are constantly becoming damaged. It gets worse as we age, experience stress, and deal with more and more free radical damage, (see previous blogs on free radicals). This is where autophagy comes in: simply put autophagy is the bodies housekeeping mechanism which involves clearing damaged cells from the body, including old cells that serve no functional purpose but still linger inside tissues and organs. The reason it’s so important to remove old and damaged cells is because they can trigger inflammatory pathways and contribute to various diseases.

Another cool thing about our housekeeping system is the autophagy process basically works by using waste produced inside cells to create new “building materials” that aid in repair and regeneration. It is our body’s most efficient cellular recycling program. Research shows autophagy:

  • Regulates the functions of the cells’ mitochondria, (the powerplant of the cell), which help produce energy while preventing damage by oxidative stress, (internal rust).
  • Clears damaged endoplasmic reticulum, (a system of cavities and tiny connecting canals that occupy much of the internal fluid of the cell and functions especially in the movement of materials within the cell).
  • Protects the nervous system and encourages growth of brain and nerve cells. Autophagy seems to improve cognitive function, brain structure and neuroplasticity.
  • Supports growth of heart cells and protects against heart disease.
  • Enhances the immune system by eliminating intracellular pathogens, (foreign invaders).
  • Defends against misfolded, toxic proteins that contribute to a number of amyloid diseases, such as Alzheimer’s and Parkinson’s disease.
  • Protects the stability of DNA.
  • Prevents damage to healthy tissues and organs.
  • Potentially fights cancer, neurodegenerative disease, and other illnesses.


Dr. Stewart has just formulated Neurobiologix’ new DCI formula
Metabolic Stimulator, which combines D-Chiro-Inositol and 4 other nutrient cofactors to enhance the necessary biochemical steps needed for intracellular energy.
Following a well-balanced diet and daily exercise can positively impact your metabolism. Adding Metabolic Stimulator to your daily routine could help regulate glucose levels and ensure insulin functions remain at their highest capabilities as well as support autophagy and help to reduce inflammation.


Detoxification

Detoxification is the result of a synergistic harmony involving:
  • Properly operating cellular functions
  • Organ and systems equilibrium
  • Cell hydration: Fluid and electrolyte balance
  • Sufficient nutrients and raw materials obtained through diet

Cellular Detoxification: A Fundamental Process

Detoxification is actually a fundamental process of all cells. It is essentially a built-in defense mechanism required to handle the end products of cellular respiration and various metabolic reactions, as well as the potentially harmful effects of exogenous toxins, which may compromise cellular functions.

In short, any type of nutritional strategy that addresses detoxification should recognize that detoxification processes are not mechanical means of affecting organs and systems, but rather, are the result of proper nutritional balancing through enhancing cellular metabolic efficiency.

Detoxification & Cellular Antioxidants

As much as there has been written about the importance of antioxidants, it is important to address that the cells of the body have built-in cellular antioxidants, which are the big defenders of the castles we call our cells. These antioxidants are continuously preventing the formation of an excess of oxidative by-products, which can form harmful free radicals. The 4 major intracellular antioxidants that are critical for detoxification include:

  • Glutathione
  • Superoxide Dismutase
  • Catalase
  • Coenzyme Q10
Glutathione is often referred to as “the mother of all antioxidants”, because it is so ubiquitously found in different cells. Glutathione is also one of the only molecules that can remove mercury. Glutathione is actually a tripeptide, consisting of 3 amino acids: cysteine, glycine and glutamine.

Superoxide dismutases (SOD’s) are enzyme/antioxidants, which degrade or “dismutize” harmful superoxides into oxygen and hydrogen peroxide. The two primary SOD’s are created from trace minerals: zinc, copper, manganese and iron.

Catalase is an antioxidant enzyme that degrades hydrogen peroxide into water and oxygen. Catalase is composed of 4 porphyrin, iron-based groups.

Coenzyme Q10 (CoQ10) is a powerful antioxidant in operation within the mitochondria of cells. It is a very important “redox” molecule, which means that it undergoes full cycles of oxidation and reduction. It can both receive and donate electrons. Mitochondria are the energy-producing factories within cells. Protecting the mitochondria from oxidative damage and potential free radical damage and cellular toxicity, is one of the most important functions of CoQ10. It is critical to understand the significance of CoQ10 as a mitochondrial antioxidant, because mitochondrial damage is one of the primary catalysts for disease processes and cellular toxicity and aging.

The organs with the highest energy requirements, liver, heart and kidneys have the highest concentrations of CoQ10. CoQ10 is depleted through cholesterol-lowering drugs and beta blockers.

Myths Regarding Detoxification

Many vegetarians and vegans incorrectly believe that restriction of animal protein is somehow detoxifying. Animal protein is rich in sulfur-containing amino acids such as cysteine and methionine, which are essential for the formation of glutathione, one of the most ubiquitous intracellular antioxidants needed for detoxification reactions. Plant protein sources contain relatively low concentrations of these important amino acids. Furthermore, obtaining amino acids (and minerals) from plants may be very difficult for the vegan, due to the presence of plant fiber, cellulose and certain enzyme inhibitors commonly found in plant foods.

Additionally, animal protein contains Vitamin B-12, not found in plant foods. B-12 is critical for liver detoxification, as well as cellular methylation reactions, which directly affect detoxification reactions in cells.

Additionally, plant-based diets tend to be low in zinc. Zinc and the sulfur-amino acid cysteine (also low in plant foods) are critical for detoxification reactions in the liver, as well as for the formation of a protein/antioxidant known as metallothionein, which can powerfully scavenge toxic metals such as mercury.

Furthermore, plant sources of iron (known as non-heme) are poorly absorbed in comparison to animal sources of iron (known as heme). Iron is pivotal for the formation of catalase and iron-based SOD, two critical intracellular antioxidants that participate in detox reactions.

Another common myth is the “alkaline diet” idea somehow being involved in detoxification. There is no evidence that exists showing how a food with an acid or alkaline pH has any influence upon systemic pH activity in the body. Proponents of the alkaline diet myth erroneously believe that urine and saliva pH can be used to determine the metabolic pH reactions from a food. Urine and saliva are not the sights of metabolic activity in the body, but rather contain residue from metabolic reactions. Furthermore, even if any food does have an ability to alter systemic pH, the influence of the lungs and the kidneys are superior in their ability to affect systemic pH activity, because the kidneys and lungs directly regulate the levels of Co2, bicarbonate and electrolytes.


"PEA For Pain" (Blog #8)
June 28, 2017

You’ve tried Curcumin, Quercetin, Bromelain, Magnesium, Omega’s, even CBD oil, and none of them seems to do the trick for your pain, right? Well, I bet you haven’t tried Palmitoylethanolamide. Okay, I’m not going to make you even try to pronounce that word. Don’t worry, you won’t have to say it to get it. That’s why we call it PEA. A lot easier right? Here’s how it works. First allow me to explain a little about the different types of nerve cells and how they work in regards to pain.

Glial cells are types of cells in the central and peripheral nervous system that are like scaffolding and glue that holds the brain and nerves together. But that’s not all they do. We have discovered that glial cells are also responsible for facilitating nerve impulses, and exerting an inflammatory response on neurons. When your glial cells get dysregulated or over-activated they can have a detrimental effect on the nervous system, causing pain.

Mast cells are a type of immune system cell that responds to chemical signals when you get injured. Remember, inflammation is not a bad thing when it does what it’s supposed to do. If you injure your arm for example, mast cells release a payload of inflammatory chemicals in the surrounding tissue. These chemicals attract white blood cells and activate their immune response against foreign invaders like bacteria to keep you from getting infected. Good thing right? Mast cells also activate pain receptors. Now you may not like that but pain lets you know -- without question – “hey, be careful with that”. But overactive mast cell activation induces an increase in the density and sensitivity of pain receptors and can play a part in a variety of chronic pain disorders. Not good!

Remember my article about CBD oil? It was discovered that mammals have a specific receptor cell known as the endocannabinoid system, which is closely interconnected with the nervous and immune system. CBD has been shown to boost every function of our cannabinoid receptors to help soothe and relax us. PEA has an affinity for the cannabinoid-like G-coupled receptors, although it has no affinity for the classical cannabinoid receptors CB1 and CB2. This is why it is sometimes referred to as a non-psychoactive “indirect endocannabinoid.” It does not block pain signals the way opioids and other analgesics do. Instead it works upstream by supporting the healthy function of glial cells and mast cells.

PEA for Pain
Because PEA tends to combine with or dissolve in lipids or fats, I recommend that you take it with some food or milk. This should help PEA dissolve and be better absorbed. Most foods will have a sufficient amount of fat to assist in dissolution, but if taken with a fat-free food it may not dissolve as well. Recommended foods to take it with are eggs, cheese, dairy, meats, salad dressings, peanut butter, coconut oil, etc. Alternatively, it may also be taken effectively with other lipid supplements such as fish oil.

Best of Health! Radhia Gleis,

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What the heck is Methylation…everybody’s talk’n about it? (Blog #7)
May 2, 2016

In my last blog, I talked about the Genomix Nutrition test. Remember? We can predict with increasing precision who is more likely to develop specific diseases; who will respond positively or react negatively to a particular drug or supplement therapy; and finally, which nutrients are optimal for a specific individual’s treatment, health, and well-being.

There are five different important categories to look at when it comes to your genomic report: Methylation, Neurotransmitter, Mitochondria, Detoxification and Inflammatory markers. So, the next five blogs I will be covering these categories in depth. So, let’s get started with the biggie. Methylation.

So...what the heck is Methylation?

Methyl groups are essential for normal DNA cell replication! They literally turn genes “on” or “off.” “Bad” genes can lead to birth defects, depression, cognitive decline, diseases and cancer and can be expressed by a depletion of your body’s methyl groups.

So… if you have depleted methyl groups and you’re exposed to a toxin, an infection, or even a severe emotional stress, then all of a sudden—whammo--you express the bad gene, which can lead to a neurodegenerative disorder like Parkinson’s, or Alzheimer’s, an autoimmune condition, or cancer.

This process of moving methyl groups around is necessary for the functioning of several biochemical reactions such as DNA and RNA synthesis, creatinine generation, immune responses involved in silencing viruses etc. Methylation reactions are involved in most body functions, to some degree. This is why compromised methylation can cause or contribute to almost all health conditions. When we look at your Genomix Nutrition profile we can determine whether you have an MTHFR polymorphism, (SNP). On average 50% or more of the population appear to have genetic weaknesses of the MTHFR enzyme, causing them to have some difficulty resynthesizing methionine from homocysteine, absorbing B12, B6 and folic acid. This can be a factor in cardiovascular disease, mental illness, and perhaps other health conditions such as fatigue and exhaustion. Methyl groups play a role in:

· Detoxification. Methylation is a primary method of removing toxins, by helping to convert fat soluble toxins to water soluble, so it can be excreted by the kidneys.

· Neurotransmitter synthesis and utilization. Methylation is part of the synthesis of dopamine and serotonin.

· Protein synthesis from our genes. Methylation is a key step in the formation of our enzymes and proteins.

· Protects the body’s telomeres. Telomeres are the “tails” on its DNA and chromosomes. As we get older these tails shorten. Methylation is involved in the preservation of these telomeres.

· Folate metabolism and cardiovascular health. Methylation is involved in converting homocysteine, back into methionine. Homocysteine is a dangerous amino acid that acts like the glue that holds plaque together in the artery.

· Hormonal regulation. Methylation is involved in balancing hormones in the liver, such as restoring the proper balance of estrogens, for example.

· Reduces inflammation by toxin removal, hormone balancing, neurotransmitter synthesis, and others.

· Helps protect the mitochondria. Methyl groups help adaptive energy production.

· Restores the level of SAMe to prevent depression, and other mental and physical effects on the body.

· Required to make coenzyme Q10. This vital substance is needed for heart health and for energy production within the mitochondria.

So, now you know how important methylation is. If you have an MTHFR SNP all of these processes can be compromised unless you have the right nutritional support. Next time we’ll talk about neurotransmitters.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner



PQQ and the Little Engine that Could (Blog #2)
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January 14, 2016


Whenever I talk to my clients about different products and their benefits, I tend to get all excited and launch into conversations with words like mitochondrial biogenesis, adenosine triphosphate, and coenzyme / cofactors and I watch their eyes glaze over as they search for the door . I realize, at that point, I better dial it back a bit, otherwise, I’ll never get them as excited, as I hope they would get about a product.

One ingredient Dr. Kendal Stewart, MD and I are excited about is PQQ or Pyrroloquinoline quinone, I know, that’s a mouthful, so let’s stick to PQQ. Although it is not currently viewed as a vitamin, it is a vitamin-like compound likely to be considered an essential nutrient in the future with a wide range of benefits to brain and body function.

Before I launch into one of my exciting discourses on mitochondrial biogenesis and such, let’s first get down to the basics, the mitochondria your cell’s power-plant.

Think of it this way: there are hundreds of muscles in our body. In each muscle there are thousands of fibers, in each fiber there are millions of microscopic sections. Every time we move a muscle, each section reflexes or contracts independently. ATP is the blast of metabolic energy that makes that happen.

It takes one molecule of ATP in order to make one of those sections have the energy to either reflex or contract just once. 36 ATP are produced from 1 glucose molecule. WOW! So obviously we need glucose but we also need all the cofactors and coenzymes, (vitamins and minerals) such as, many of our B vitamins, to make just 36 molecule of ATP. Like the engine in a locomotive, this is all done in the mitochondria.

In order to increase mitochondrial output, there must be adequate fuel supply for combustion and abundant antioxidants to scavenge free radical by-products. Think of free-radicals as the rust on your car when the paint is oxidized. That can actually happen to your tissue cells, otherwise known as oxidative stress or rust J Anti-oxidants keep us from--rusting. PQQ is also an extremely powerful antioxidant compared to other antioxidants. For example, PQQ is able to carry out 20,000 catalytic conversions compared to only 4 for vitamin C.

Preserving our energy reserves and increasing energy output is a critical part of maintaining optimal health. There are many things that can drain energy reserves. Lack of sleep, too much stress, poor nutrition, and prescription medications can draw on our energy reserves using them up faster than they can be replenished.

PQQ not only protects mitochondria from oxidative stress—it also promotes the spontaneous generation of new mitochondria within aging cells, a process known as mitochondrial biogenesis. There I go again! Suffice to say, this effect is a “fountain of youth” for mitochondrial function.

Here is an interesting factoid: PQQ has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution.

Current research has primarily focused on its ability to protect memory and cognition in both aging animals and humans. Here are just some of the effects noted in these studies:

  • PQQ reverses cognitive impairment caused by chronic oxidative stress and improve performance on memory tests.
  • PQQ supplementation stimulates the production and release of nerve growth factor.
  • PQQ protects brain cells against oxidative damage in models of strokes.
  • PQQ protects the brain against neurotoxicity induced by other powerful toxins, including mercury, and glutamate.
  • PQQ prevents development of a protein associated with Parkinson’s disease.
  • PQQ also protects nerve cells from the damaging effects of the beta-amyloid-protein linked with Alzheimer’s disease.

The product that I like is Mito Cell PQQ by NeuroBiologix. The great thing about Mito Cell PQQ is that it is PQQ and CoQ10 combined with 7 other amazing ingredients. Why is that great? Because now that we know what PQQ is, CoQ10 in the ignition of the cell, like the ignition in your car, it turns on the engine. Brilliant product!!

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com


What the Heck is NADH and Who Needs It Anyway? (Blog #2)

January 22, 2016

If you saw my last blog post entitled: PQQ and the Little Engine that Could , I talked about what PQQ is and ATP, and NADH and CoQ10 and…okay I can feel your eyes about to glaze over already, but before you move that mouse this will be good, I promise.

Let’s recap. ATP is that blast of energy we talked about, remember, you need that ATP blast to reflex or contract each little section of your muscle fibers to even move a muscle, let alone, breath or think or stay alive, unless you’re a zombie of course, but I’m not sure what the biochemistry of a zombie is, so let’s assume you’re not one. Suffice to say, ATP—good to have! And in order to make ATP, it takes food molecules such as glucose, (blood sugar) that are converted in the mitochondria, (remember that little engine of the cell), into ATP. This is called the Kreb cycle. Okay, enough, this is the one area of biochemistry that I HATED. So I won’t bore you with anymore except to mention, this is through a process called cellular respiration where these food molecules are oxidized.

Now, why did I have to go and mention that? I promised you this was going to be good and it’s already sounding like that class in high school that we all couldn’t wait for the bell to ring. Well, hang with me, I’m trying to connect the dots. So let’s connect – food molecules are oxidized – and when something is oxidized it causes—that’s right – rust. Ah ha, PQQ is a powerful anti-oxidant.

Now it’s all coming back and CoQ10 is the ignition on the cell and NADH is….oh wait, I didn’t tell you that yet. Well I promise you I’m not going to talk about hydrogen atoms being removed and enzymes and coenzymes and all that, just know that NADH is a part of the Kreb cycle that spits out an ATP molecule. Yey!

So NADH—good to have. Without it we can’t make ATP. So why would you want to take the supplement NADH? Because some folks genetically do not convert NADH very well. These are the folks whos get up and go, got up and went. And now you know why.

This is why we are so excited about MitoCell PQQ, Mito, (mitochondria), Cell. Cause the formula it has in it, all the elements to make your engine run and your brain to function properly; PQQ the antioxidant, CoQ10 the ignition and the main cog in the engine, NADH, that makes the turn of the Kreb cycle in order to spit out a molecule the ATP, (metabolic energy).

Oh yeah, and then there is Acetyl L-Carnitine. Well, maybe next time.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com


Acetyl What? (Blog #3)

February 2, 2016

Acetyl L’Carnitine! If you have been following my blog so far we are talking about Neurobiologix exciting new product Mito Cell PQQ. Just to recap, we talked about PQQ the antioxidant with the ability to carry out 20,000 catalytic conversions compared to only 4 for vitamin C, CoQ10 the ignition of the cell and now we’re going to talk about acetyl l’carnitine. Acetyl l’carnitine is synthesized to provide a more bioavailable form of L-carnitine. Derived from the amino acid lysine, L-carnitine is made naturally in the body by the liver and kidneys, and then transported to other tissues such as the brain and heart.

Like L-carnitine, and PQQ acetyl-L-carnitine functions as an antioxidant and promotes the production of glutathione, a free radical scavenger, in cells.

Because L-carnitine is involved in cellular metabolism, acetyl-L-carnitine is even better to help increase energy production in the mitochondria, the "power plant" of all cells, and thereby may generally boost physical and mental energy.

Here’s how it works: when triglycerides, (tri meaning 3 blood fats) are transported to the cell an enzyme breaks them up into single fat molecules and puts them into a “carnitine shuttle” like little box cars that shuttle the fat into the mitochondria to burn as fuel. That’s one reason why many trainers recommend taking l’carnitine for your workout. It helps to burn fat and create more energy.

As a dietary supplement, acetyl-L-carnitine is also often used to help improve memory, and studies have shown it to be a possible adjunct treatment for Alzheimer's disease. As for other benefits, daily supplementation with acetyl-L-carnitine may have a protective effect on the central nervous system and may benefit the heart. In addition, i t may help address symptoms of depression, and may even be useful in the treatment of Parkinson's disease, stroke, and traumatic brain injury.

Acetyl l’carnitine comes in the MitoCell but Neurobiologix also sells it by itself.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com