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What the heck is Methylation…everybody’s talk’n about it?
(Blog #7)
May 2, 2016

In my last blog, I talked about the Genomix Nutrition test. Remember? We can predict with increasing precision who is more likely to develop specific diseases; who will respond positively or react negatively to a particular drug or supplement therapy; and finally, which nutrients are optimal for a specific individual’s treatment, health, and well-being.

There are five different important categories to look at when it comes to your genomic report: Methylation, Neurotransmitter, Mitochondria, Detoxification and Inflammatory markers. So, the next five blogs I will be covering these categories in depth. So, let’s get started with the biggie. Methylation.

So...what the heck is Methylation?

Methyl groups are essential for normal DNA cell replication! They literally turn genes “on” or “off.” “Bad” genes can lead to birth defects, depression, cognitive decline, diseases and cancer and can be expressed by a depletion of your body’s methyl groups.

So… if you have depleted methyl groups and you’re exposed to a toxin, an infection, or even a severe emotional stress, then all of a sudden—whammo--you express the bad gene, which can lead to a neurodegenerative disorder like Parkinson’s, or Alzheimer’s, an autoimmune condition, or cancer.

This process of moving methyl groups around is necessary for the functioning of several biochemical reactions such as DNA and RNA synthesis, creatinine generation, immune responses involved in silencing viruses etc. Methylation reactions are involved in most body functions, to some degree. This is why compromised methylation can cause or contribute to almost all health conditions. When we look at your Genomix Nutrition profile we can determine whether you have an MTHFR polymorphism, (SNP). On average 50% or more of the population appear to have genetic weaknesses of the MTHFR enzyme, causing them to have some difficulty resynthesizing methionine from homocysteine, absorbing B12, B6 and folic acid. This can be a factor in cardiovascular disease, mental illness, and perhaps other health conditions such as fatigue and exhaustion. Methyl groups play a role in:

· Detoxification. Methylation is a primary method of removing toxins, by helping to convert fat soluble toxins to water soluble, so it can be excreted by the kidneys.

· Neurotransmitter synthesis and utilization. Methylation is part of the synthesis of dopamine and serotonin.

· Protein synthesis from our genes. Methylation is a key step in the formation of our enzymes and proteins.

· Protects the body’s telomeres. Telomeres are the “tails” on its DNA and chromosomes. As we get older these tails shorten. Methylation is involved in the preservation of these telomeres.

· Folate metabolism and cardiovascular health. Methylation is involved in converting homocysteine, back into methionine. Homocysteine is a dangerous amino acid that acts like the glue that holds plaque together in the artery.

· Hormonal regulation. Methylation is involved in balancing hormones in the liver, such as restoring the proper balance of estrogens, for example.

· Reduces inflammation by toxin removal, hormone balancing, neurotransmitter synthesis, and others.

· Helps protect the mitochondria. Methyl groups help adaptive energy production.

· Restores the level of SAMe to prevent depression, and other mental and physical effects on the body.

· Required to make coenzyme Q10. This vital substance is needed for heart health and for energy production within the mitochondria.

So, now you know how important methylation is. If you have an MTHFR SNP all of these processes can be compromised unless you have the right nutritional support. Next time we’ll talk about neurotransmitters.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner



PQQ and the Little Engine that Could (Blog #2)
Click Here To Download: http://www.neurobiologix.com/v/vspfiles/assets/PDFs/PQQLittleEnginethatCould.pdf
January 14, 2016


Whenever I talk to my clients about different products and their benefits, I tend to get all excited and launch into conversations with words like mitochondrial biogenesis, adenosine triphosphate, and coenzyme / cofactors and I watch their eyes glaze over as they search for the door . I realize, at that point, I better dial it back a bit, otherwise, I’ll never get them as excited, as I hope they would get about a product.

One ingredient Dr. Kendal Stewart, MD and I are excited about is PQQ or Pyrroloquinoline quinone, I know, that’s a mouthful, so let’s stick to PQQ. Although it is not currently viewed as a vitamin, it is a vitamin-like compound likely to be considered an essential nutrient in the future with a wide range of benefits to brain and body function.

Before I launch into one of my exciting discourses on mitochondrial biogenesis and such, let’s first get down to the basics, the mitochondria your cell’s power-plant.

Think of it this way: there are hundreds of muscles in our body. In each muscle there are thousands of fibers, in each fiber there are millions of microscopic sections. Every time we move a muscle, each section reflexes or contracts independently. ATP is the blast of metabolic energy that makes that happen.

It takes one molecule of ATP in order to make one of those sections have the energy to either reflex or contract just once. 36 ATP are produced from 1 glucose molecule. WOW! So obviously we need glucose but we also need all the cofactors and coenzymes, (vitamins and minerals) such as, many of our B vitamins, to make just 36 molecule of ATP. Like the engine in a locomotive, this is all done in the mitochondria.

In order to increase mitochondrial output, there must be adequate fuel supply for combustion and abundant antioxidants to scavenge free radical by-products. Think of free-radicals as the rust on your car when the paint is oxidized. That can actually happen to your tissue cells, otherwise known as oxidative stress or rust J Anti-oxidants keep us from--rusting. PQQ is also an extremely powerful antioxidant compared to other antioxidants. For example, PQQ is able to carry out 20,000 catalytic conversions compared to only 4 for vitamin C.

Preserving our energy reserves and increasing energy output is a critical part of maintaining optimal health. There are many things that can drain energy reserves. Lack of sleep, too much stress, poor nutrition, and prescription medications can draw on our energy reserves using them up faster than they can be replenished.

PQQ not only protects mitochondria from oxidative stress—it also promotes the spontaneous generation of new mitochondria within aging cells, a process known as mitochondrial biogenesis. There I go again! Suffice to say, this effect is a “fountain of youth” for mitochondrial function.

Here is an interesting factoid: PQQ has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution.

Current research has primarily focused on its ability to protect memory and cognition in both aging animals and humans. Here are just some of the effects noted in these studies:

  • PQQ reverses cognitive impairment caused by chronic oxidative stress and improve performance on memory tests.
  • PQQ supplementation stimulates the production and release of nerve growth factor.
  • PQQ protects brain cells against oxidative damage in models of strokes.
  • PQQ protects the brain against neurotoxicity induced by other powerful toxins, including mercury, and glutamate.
  • PQQ prevents development of a protein associated with Parkinson’s disease.
  • PQQ also protects nerve cells from the damaging effects of the beta-amyloid-protein linked with Alzheimer’s disease.

The product that I like is Mito Cell PQQ by NeuroBiologix. The great thing about Mito Cell PQQ is that it is PQQ and CoQ10 combined with 7 other amazing ingredients. Why is that great? Because now that we know what PQQ is, CoQ10 in the ignition of the cell, like the ignition in your car, it turns on the engine. Brilliant product!!

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com


What the Heck is NADH and Who Needs It Anyway? (Blog #2)

January 22, 2016

If you saw my last blog post entitled: PQQ and the Little Engine that Could , I talked about what PQQ is and ATP, and NADH and CoQ10 and…okay I can feel your eyes about to glaze over already, but before you move that mouse this will be good, I promise.

Let’s recap. ATP is that blast of energy we talked about, remember, you need that ATP blast to reflex or contract each little section of your muscle fibers to even move a muscle, let alone, breath or think or stay alive, unless you’re a zombie of course, but I’m not sure what the biochemistry of a zombie is, so let’s assume you’re not one. Suffice to say, ATP—good to have! And in order to make ATP, it takes food molecules such as glucose, (blood sugar) that are converted in the mitochondria, (remember that little engine of the cell), into ATP. This is called the Kreb cycle. Okay, enough, this is the one area of biochemistry that I HATED. So I won’t bore you with anymore except to mention, this is through a process called cellular respiration where these food molecules are oxidized.

Now, why did I have to go and mention that? I promised you this was going to be good and it’s already sounding like that class in high school that we all couldn’t wait for the bell to ring. Well, hang with me, I’m trying to connect the dots. So let’s connect – food molecules are oxidized – and when something is oxidized it causes—that’s right – rust. Ah ha, PQQ is a powerful anti-oxidant.

Now it’s all coming back and CoQ10 is the ignition on the cell and NADH is….oh wait, I didn’t tell you that yet. Well I promise you I’m not going to talk about hydrogen atoms being removed and enzymes and coenzymes and all that, just know that NADH is a part of the Kreb cycle that spits out an ATP molecule. Yey!

So NADH—good to have. Without it we can’t make ATP. So why would you want to take the supplement NADH? Because some folks genetically do not convert NADH very well. These are the folks whos get up and go, got up and went. And now you know why.

This is why we are so excited about MitoCell PQQ, Mito, (mitochondria), Cell. Cause the formula it has in it, all the elements to make your engine run and your brain to function properly; PQQ the antioxidant, CoQ10 the ignition and the main cog in the engine, NADH, that makes the turn of the Kreb cycle in order to spit out a molecule the ATP, (metabolic energy).

Oh yeah, and then there is Acetyl L-Carnitine. Well, maybe next time.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com


Acetyl What? (Blog #3)

February 2, 2016

Acetyl L’Carnitine! If you have been following my blog so far we are talking about Neurobiologix exciting new product Mito Cell PQQ. Just to recap, we talked about PQQ the antioxidant with the ability to carry out 20,000 catalytic conversions compared to only 4 for vitamin C, CoQ10 the ignition of the cell and now we’re going to talk about acetyl l’carnitine. Acetyl l’carnitine is synthesized to provide a more bioavailable form of L-carnitine. Derived from the amino acid lysine, L-carnitine is made naturally in the body by the liver and kidneys, and then transported to other tissues such as the brain and heart.

Like L-carnitine, and PQQ acetyl-L-carnitine functions as an antioxidant and promotes the production of glutathione, a free radical scavenger, in cells.

Because L-carnitine is involved in cellular metabolism, acetyl-L-carnitine is even better to help increase energy production in the mitochondria, the "power plant" of all cells, and thereby may generally boost physical and mental energy.

Here’s how it works: when triglycerides, (tri meaning 3 blood fats) are transported to the cell an enzyme breaks them up into single fat molecules and puts them into a “carnitine shuttle” like little box cars that shuttle the fat into the mitochondria to burn as fuel. That’s one reason why many trainers recommend taking l’carnitine for your workout. It helps to burn fat and create more energy.

As a dietary supplement, acetyl-L-carnitine is also often used to help improve memory, and studies have shown it to be a possible adjunct treatment for Alzheimer's disease. As for other benefits, daily supplementation with acetyl-L-carnitine may have a protective effect on the central nervous system and may benefit the heart. In addition, i t may help address symptoms of depression, and may even be useful in the treatment of Parkinson's disease, stroke, and traumatic brain injury.

Acetyl l’carnitine comes in the MitoCell but Neurobiologix also sells it by itself.

Best of Health!

Radhia Gleis, Wellness Director,

Radhia Gleis, CCN, is a Board Certified Clinical Nutritionist/Holistic Practitioner, Wellness Director for Martins Compounding & Wellness Pharmacies with three locations in the Austin area. She is available for private consultation at the LakeHills Pharmacy, M-F, 1:30 to 6:30pm. Contact Radhia@cpdwellness.com