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MTHFR is a a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body's methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene's role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as 'mutations' or 'defects' because of the problems they cause in the body.

Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective.

Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body's ability to methylate or convert folic acid from the food we eat into Methylfolate.

Methylfolate is most often referred to as the 'active' or usable form of folate that our cells require. Because the body's cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it . It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.

The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered 'common' defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).

Everyone receives one copy of the MTHFR gene from each parent. This means a person could have any one of the following combinations as well as the issues that go with it:

Normal / Normal - Normal for the two common variants, or mutations, 677 and 1298 (no mutation is evident) 



Normal / C677T - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

Normal / A1298C - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)

A1298C / A1298C - Denoted as 1298CC - Much worse for the above problems (referred to as Homozygous) 



C677T / C677T - Denoted as 677TT - Similar to 1298CC plus heart disease, blood clots, and more (referred to as Homozygous) 


C677T / A1298C - Susceptible to all of the above and worse for strokes, heart disease, blood clots, etc. (referred to as Compound Heterozygous)

Heterozygous A1298C or C677T or other symptoms of a methylation deficiency: Provide Methylation Complete Sublingual or Neuro-Immune Stabilizer twice daily and as directed on label.

Homozygous for 1298 or C677 or combination: Provide Methylation Complete Sublingual OR Neuro-Immune Stabilizer twice daily for 2 weeks then add Methyl Folate Plus 1-2x’s daily (Niacinamide is an ingredient in the Methyl Folate Plus to support mitochondria and delivery of tetrahydrofolate).

Statement from Dr. Stewart: Many abnormalities (high folic acid in blood serum, low or high homocysteine, MTHFR mutation / heterozygous or homozygous) can point to a methylation deficiency. I find that many of my patients will respond better if you ease into the methylation protocol. Suggested use is begin with the Methylation Complete Sublingual OR Neuro-Immune Stabilizer Cream for about 2 weeks by itself and then add the Methyl Folate Plus if you feel it is necessary or with a homozygous result or heterozygous compound polymorphism result.

"Putting too much in too quickly can backfire on your symptomatically."


Nutritional Recommendations:



Methylation Complete Sublingual
Neuro-Immune Stabilizer Topical Cream.



Helpful Videos/ Audio
5 minute Video: “Methylation For Patients with Kendal Stewart, MD” click on link:

Methylation Overview For Patients by Kendal Stewart, MD from Neurobiologix on Vimeo.

Podcast on Coffee With Dr. Stewart Radio: Episode 13 On Genetic Testing,
Mutations and What They Mean
www.coffeewithdrstewart.podbean.com

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5 MTHF supplement L-5-MTHF - 60 Capsules

L-5-MTHF (5-Methyltetrahydrofolate) is the most common biologically active form of the water soluble B vitamin, folate. Folate must be converted to its active forms to be used by the body. This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs.

Folate deficiencies are common as many individuals do not consume enough folate-rich foods and dietary folates are readily destroyed by cooking or processing. Although typically included in multivitamins, some individuals do not effectively methylate and convert folic acid, the form of folate commonly found in fortified foods and supplements, into its active form thus are still at risk of deficiency. Metafolin® L-5-MTHF, an active, methylated form of folate, requires no additional metabolic steps to be used by the body, thus it is often the preferred choice for those with absorption or metabolic defects. L-MethylFolate efficiently supports methylation, DNA biosynthesis, homocysteine metabolism, and nervous system function. Supplies 1 mg (1,000 mcg) folate per capsule.
It is estimated that up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.

OUR PRICE: $22.90
Neuro Methylation Sublingual Methylation Complete - 120 Fast Dissolve Tablets

Bioactive B6, B12 & Methyl Folate
Fast Dissolving Tablet For Ultimate Methylation Support

Dissolves in 60 Seconds and Tastes Great!

Our unique delivery system assures that our pharmaceutical grade Methylation Complete™ promotes and enhances the methylation processes needed to improve the production of glutathione, and allow maximum B12, B6 and 5-MTHF (bioactive and methylated form of folate) delivery to the nervous and immune systems.

Fast-dissolving tablets allow for quick release into the bloodstream. Vitamin B12 and folate play an integral role in DNA synthesis and thus are essential to cell division and proper functioning of virtually all tissues in the body. Active B12 and Folate may be especially beneficial for persons who are vegetarian or with impaired gastrointestinal absorption due to aging, illness, surgery or a methylation deficiency.

This fast dissolving tablet may help maximize and aid in:
  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR / MTRR Mutations
  • Short Term Memory
  • Sleep Patterns
  • Immune Health
Methylation Complete Sublingual Product Video with Dr. Stewart on Vimeo.

OUR PRICE: $53.90
neuro methylation cream Neuro-Immune Stabilizer Topical Cream (120 pumps)

Topical Cream for Methylation, Neurological, Nervous & Immune System Support

As a solution, our unique topical delivery system, assures that our pharmaceutical grade Neuro-Immune Stabilizer Cream promotes and enhances the methylation processes needed to improve the production of glutathione, increase Vitamin D levels and allow maximum B12, B6 and vitamin delivery to the nervous and immune systems. This potent nutrient-rich cream may help maximize and aid in:
  • Mood Improvement & Stabilization
  • Mental Focus & Concentration
  • Organization Skills
  • MTHFR mutations
  • Short Term Memory
  • Cerebral Folate Deficiency
  • Hormonal Regulation
  • Support a health sleep cycle
  • Immune Function
Such nutrients as Pyridoxal 5-Phosphate (B6) and Vitamin B12 in a methylated form called methylcobalamin (Methyl B12) and hydroxycobalamin (Hydroxy B12) and natural Vitamin D assist the body neurologically and physically.

It is estimated that roughly one in three Americans have genetically inefficient enzymes that help create 5-MTHF (folinic acid) so this cream will assist with supplying the 5-MTHF for optimal help.


OUR PRICE: $55.90
Glutathione (Reduced L-Glutathione) 150mg per capsule / 100 Capsules

150mg per capsule of the active form of L-Glutathione!

Enhancing the Immune System
- Your bodies immune activity, involving unimpeded multiplication of lymphocytes and antibody production, requires maintenance of normal levels of glutathione inside the lymphocytes.
Antioxidant and Free Radical Scavenger - Glutathione plays a central protective role against the damaging effects of bacteria, viruses, pollutants and free radicals.

Regulator of Other Antioxidants - Without glutathione, other important antioxidants such as vitamins C and E cannot do their job adequately to protect your body against disease.

A Detoxifying Agent - Another major function of glutathione is in the detoxification of foreign chemical compounds such as carcinogens and harmful metabolites.

OUR PRICE: $61.90